331001-07-1Relevant academic research and scientific papers
Candida antarctica lipase-catalyzed hydrolysis of 4-substituted bis(ethoxycarbonylmethyl) 1,4-dihydropyridine-3,5-dicarboxylates as the key step in the synthesis of optically active dihydropyridines
Sobolev, Arkadij,Franssen, Maurice C.R,Makarova, Natalija,Duburs, Gunars,De Groot, Aede
, p. 4559 - 4569 (2000)
Prochiral bis(ethoxycarbonylmethyl) substituted 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates were hydrolyzed enantioselectively by Candida antarctica lipase B (Novozym 435). The enantiomeric excesses varied from 68 to 93%, depending on the substituent at
