33108-89-3

Usage

Uses

Used in Organic Synthesis:
(1Z)-N-hydroxy-2-(4-methylphenyl)-2-oxoethanimidoyl chloride serves as a key intermediate in organic synthesis, facilitating the creation of complex molecular structures. Its reactivity allows for the formation of various chemical bonds, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1Z)-N-hydroxy-2-(4-methylphenyl)-2-oxoethanimidoyl chloride is utilized as a building block for the development of new drugs. Its capacity to interact with biological targets makes it a promising candidate for the design of molecules with therapeutic potential.
Used in Drug Design and Development:
(1Z)-N-hydroxy-2-(4-methylphenyl)-2-oxoethanimidoyl chloride is employed as a structural element in drug design and development. Its presence in a molecule can influence the pharmacokinetic and pharmacodynamic properties, contributing to the overall effectiveness and safety of a drug.
Used in Chemical Reactions and Processes:
(1Z)-N-hydroxy-2-(4-methylphenyl)-2-oxoethanimidoyl chloride is also used in various chemical reactions and processes outside of the pharmaceutical industry. Its unique properties enable it to participate in a wide array of transformations, making it a versatile tool in the chemical industry for the production of diverse chemical products.

Upstream product

• 17628-76-1 p-tolylglyoxalmonoxime 
• 122-00-9 para-methylacetophenone 
• 544-16-1 n-Butyl nitrite 
• 4209-24-9 p-methylphenacyl chloride 

Downstream Products

• 99-94-5 p-Toluic acid 
• 53360-85-3 2-amino-1-(4-methylphenyl)ethanol 
• 143962-59-8 chloro-p-tolylglyoxime 
• 58144-64-2 (4-methylphenyl)(5-phenyl-1,2-oxazol-3-yl)methanone 
• 102356-84-3 4-[3-(4-toluoyl)isoxazol-5-yl]butan-1-ol 
• 102356-78-5 2-[3-(4-toluoyl)isoxazol-5-yl]ethanol 
• 1100744-79-3 4-(5-methyl-1-phenyl-1H-pyrazol-4-carbonyl)-3-(4-methylbenzoyl)isoxazole 
• 102941-51-5 S-2-(N,N-dimethylamino)ethyl (4'-methylbenzoyl)thioformohydroximate 
• 102252-38-0 isopropyl [3-(4-toluoyl)-1,2,4-oxadiazol-5-yl]acetate 
• 102252-33-5 [3-(4-Toluoyl)-1,2,4-oxadiazol-5-yl]acetamide 
• 102252-43-7 [3-(4-toluoyl)-1,2,4-oxadiazol-5-yl]acetic acid 
• 68659-12-1 C'-(4-bromo-phenyl)-C-p-tolyl-C,C'-isoxazole-3,5-diyl-bis-methanone 
• 68659-06-3 C,C'-di-p-tolyl-C,C'-isoxazole-3,5-diyl-bis-methanone 

Relevant academic research and scientific papers

Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of α-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro

In the search for improved lipophilic centrally active acetylcholinesterase (AChE) antidotes, a series of α-keto thiohydroximates were prepared and evaluated for their ability to reactivate AChEs inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and soman (GD). The compounds conformed to the general structure 4-RC6H5C-(O)C(NOH)S(CH2)(n)N+R'R''·X- where R = H, CH3, F, Br, Cl, OCH3, CN; R' = CH3, C2H5, i-C3H7; R'' = H, CH3; X = Cl, I; and n = 2, 3. In this series, varying R substituents on the aryl ring produced compounds with oxime pK(a) values from 6.8 to 8.0, optimum for an AChE reactivator. Increasing lipophilicity of the amine segment correlated with reactivator potency, as did electron-withdrawing groups on the aryl moiety, presumably due to increased binding to hydrophobic sites surrounding the AChE active site. The in vitro reactivation potency of the α-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. These initial findings point to additional structure-activity relationships to assist in the design of improved antidotal compounds.