33118-85-3

Usage

Uses

Used in Pharmaceutical Industry:
AKOS AKM00984 is used as a therapeutic agent for the treatment of mood disorders such as depression and anxiety. It operates by increasing the levels of key neurotransmitters, which are often depleted in individuals with these conditions, thereby potentially improving mood and cognitive function.
Used in Neuroprotective Applications:
AKOS AKM00984 is used as a neuroprotective agent to potentially safeguard neurons from damage or degeneration, which could be beneficial in conditions characterized by neuronal loss or impairment.
Used in Cognitive Enhancement:
AKOS AKM00984 is used as a cognitive enhancer to potentially improve cognitive functions, which may be particularly relevant for conditions associated with cognitive decline or for enhancing cognitive performance in healthy individuals.
Used in Research and Development:
AKOS AKM00984 is used as a subject of research in the development of new treatments for various neurological and psychiatric conditions, given its potential to modulate neurotransmitter levels and its neuroprotective and cognitive enhancing properties.

InChI:InChI=1/C9H7BrO/c1-6-5-11-9-3-2-7(10)4-8(6)9/h2-5H,1H3

Upstream product

• 73444-63-0 Acetic acid (E)-2-(5-bromo-2-hydroxy-phenyl)-propenyl ester 
• 73444-59-4 Acetic acid 4-bromo-2-(2-methyl-oxiranyl)-phenyl ester 
• 34849-51-9 (2-acetyl-4-bromophenoxy)acetic acid 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 1761-61-1 5-bromosalicyclaldehyde 
• 90-02-8 salicylaldehyde 
• 34849-50-8 (2-acetyl-4-bromophenoxy)acetic acid ethyl ester 

Downstream Products

• 50638-09-0 1-(5-bromo-3-methylbenzofuran-2-yl)ethanone 
• 648449-50-7 3-methylbenzofuran-5-carbaldehyde 
• 1396753-10-8 3-methyl-5-(4 ,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzofuran 
• 188714-70-7 5-[2-(2-Bromo-3-bromomethyl-benzofuran-5-yl)-phenyl]-1-trityl-1H-tetrazole 
• 188714-69-4 5-[2-(3-Bromomethyl-benzofuran-5-yl)-phenyl]-1-trityl-1H-tetrazole 
• 188714-68-3 5-[2-(3-Methyl-benzofuran-5-yl)-phenyl]-1-trityl-1H-tetrazole 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS

This invention relates to the use of triazolone derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones in the treatment of cancer.

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b] furans and their BLT1 and/or BLT2 inhibitory activities

Several 2-alkylcarbamoyl-1-alkylvinylbenzo[b]furans were designed to find a selective leukotriene B4 (LTB4) receptor antagonist. 2-(2-Alkylcarbamoyl-1-alkylvinyl)benzo[b]furans having a substituent group at the 3-position, 4-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans having a substituent group at the 3-position, and 7-(2-alkylcarbamoyl-1-methylvinyl) benzo[b]furans and 3-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans were prepared and evaluated for LTB4 receptor (BLT1 and BLT 2) inhibitory activities. (E)-3-Amino-4-[2-[2-(3,4-dimethoxyphenyl) ethylcarbamoyl]-1-methylvinyl]benzo[b]furan ((E)-17c) showed potent and selective inhibitory activity for BLT2. On the other hand, (E)-7-(2-diethylcarbamoyl-1-methylvinyl)benzo[b]furan ((E)-27a) showed potent inhibitory activity for both BLT1 and BLT2. This journal is The Royal Society of Chemistry.

The conformation and activity relationship of benzofuran derivatives as angiotensin II receptor antagonists

We have synthesized various benzofuran derivatives to study the relationship between the conformation and the angiotensin II type I receptor antagonistic activity.

Thermal Rearrangement of 2-Methyl-2-(2'-acetoxy-5'-methylphenyl)oxirane

Thermal rearrangement of 2-methyl-(2'-acetoxy-5'-methylphenyl)oxirane (2) at 160 deg C for 1 hr furnishes a mixture of 2-(2'-hydroxy-5'-methylphenyl)propenyl acetate (4), 3,5-dimethylbenzofuran (11), 2-(2'-acetoxy-5'-methylphenyl)-propenyl acetate (5), 2-hydroxy-5-methylacetophenone (13), (+/-)-2,3-dihydro-3α,5-dimethylbenzofuran-2β-ol (14) and (+/-)-2,3-dihydro-3β,5-dimethylbenzofuran-2β-ol (15).Evidences in support of E-geometry at the ethylenic linkage of enolester (4) are presented.Treatment of 4 with alkali in the presence of air furnishes 13.Oxidation of a mixture of 14 and 15 gives 2,3-dihydro-3,5-dimethylbenzofuran-2-one (19). 3,5-Dimethylbenzofuran (11) has been prepared from 4.Thermal rearrangement of 2-methyl-(2'-acetoxy-5'-bromophenyl)oxirane (27) furnishes 5-bromo-3-methylbenzofuran (12) in good yield.