3313-85-7

Basic information

• Product Name: bicyclo[3.1.0]hex-6-ylmethanol
• Synonyms: Bicyclo[3.1.0]hexane-6-methanol
• CAS NO: 3313-85-7
• Molecular Formula: C₇H₁₂O
• Molecular Weight: 112.1696
• Mol File: 3313-85-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 189.2°C at 760 mmHg
• Flash Point: 82.3°C
• Density: 1.057g/cm³
• Vapor Pressure: 0.158mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: bicyclo[3.1.0]hex-6-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: bicyclo[3.1.0]hex-6-ylmethanol(3313-85-7)
• EPA Substance Registry System: bicyclo[3.1.0]hex-6-ylmethanol(3313-85-7)

Safety Data

• Hazardous Substances Data: 3313-85-7(Hazardous Substances Data)

Upstream product

• 72229-06-2 ethyl bicyclo<3.1.0>hexane-6-carboxylate 
• 54561-38-5 bicyclo<3.1.0>hex-2-en-6-ylmethanol 
• 142-29-0 cyclopentene 

Downstream Products

• 1363359-92-5 7-(bicyclo[3.1.0]hexan-6-ylmethoxy)-N-(4-(3-chloro-4-fluorophenyl))-6-nitroquinazolin-4-amine 
• 1363569-78-1 (E)-N-(7-((bicyclo[3.1.0]hexan-6-yl)methoxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 
• 1363359-93-6 7-(bicyclo[3.1.0]hexan-6-ylmethoxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine 
• 1314903-58-6 6-(chloromethyl)-exobicyclo[3.1.0]hexane 
• 60775-79-3 6-Brommethylbicyclo<3.1.0>hexan 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR MODULATING FXR

The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).

THIAZOLE CARDIOVASCULAR AGENTS

1-Alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propan ol;5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene-N-alkyloxazol idin e and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolid ines and derivatives are also intermediates for the 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols . The 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolid ine or derivative; or by treatment of the corresponding 3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine. Similarly the 5-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolid ine or derivative can be prepared from the corresponding 1-alkylamino-3-(5-carbocyclicalkylaminocarbonylthiazol-2-yloxy)-2-propanols via treatment with an aldehyde or ketone.