33143-89-4

Basic information

• Product Name: 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene
• Synonyms: 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene
• CAS NO: 33143-89-4
• Molecular Weight: 190.242
• Mol File: 33143-89-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene(33143-89-4)
• EPA Substance Registry System: 1-(1,1-dimethyl-2-propynyloxy)-4-methoxy benzene(33143-89-4)

Safety Data

• Hazardous Substances Data: 33143-89-4(Hazardous Substances Data)

Upstream product

• 6214-31-9 3-bromo-3-methylbut-1-yne 
• 150-76-5 4-methoxy-phenol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 61570-79-4 1,1-dimethyl-2-propynyl trifluoroacetate 
• 19021-53-5 methyl (2-methylbut-3-yn-2-yl)carbonate 
• 1111-97-3 3-chloro-3-methylbut-1-yne 

Downstream Products

• 1422963-27-6 4β-[(4-(2-(4-methoxyphenoxy)propan-2-yl)-1H-1,2,3-triazol-1-yl)]-4-desoxypodophyllotoxin 
• 1565830-21-8 (E)-(3-(4-methoxyphenoxy)-3-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-1-en-1-yl)dimethyl(phenyl)silane 
• 1400817-60-8 (E)-triethyl(3-(4-methoxyphenoxy)-3-methylbut-1-enyl)silane 
• 22927-97-5 6-methoxy-2,2-dimethyl-2H-chromene 
• 1263863-04-2 6,6'-dimethoxy-2,2,2',2'-tetramethyl-2H,2'H-3,3'-bichromene 
• 25974-58-7 4-methoxy-2-(3-methylbut-2-enyl)phenol 
• 117543-33-6 1-(3-Chloro-1,1-dimethyl-prop-2-ynyloxy)-4-methoxy-benzene 
• 115997-69-8 1-(3-Bromo-1,1-dimethyl-prop-2-ynyloxy)-4-methoxy-benzene 
• 34125-71-8 1-methoxy-4-((2-methylbut-3-en-2-yl)oxy)benzene 

Relevant articles and documents

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2 H-Chromenes

Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system 56, and their Au(I)-catalyzed cyclization (intramolecular hydroarylation) to give the corresponding coumarins (e.g., 1). Simple syntheses of natural products such as ayapin (144) and scoparone (145) have been realized by such means, and the first of these subject to single-crystal X-ray analysis. A related process is described for the conversion of propargyl ethers such as 156 into the isomeric 2H-chromene precocene I (159), a naturally occurring inhibitor of juvenile hormone biosynthesis.

Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells

A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin congeners were synthesized by employing click chemistry and further evaluated for their antitumor activity by MTT assay. Among them, six congeners (10, 11, 12, 13, 22, and 24) exhibited ap

Ph3PAuNTf2 as a superior catalyst for the selective synthesis of 2H-chromenes: Application to the concise synthesis of benzopyran natural products

Ph3PAuNTf2 (≈1 mol-%) catalyzes the selective cycloisomerization of substituted aryl propargyl ethers into 2H-chromenes in excellent yields. Benzofuran byproducts are formed only in the case of electron-deficient arenes, in up to 7% relative yield. The Ph 3PAuNTf2-catalyzed cyclization of aryl propargyl ethers was applied as a key step to the concise synthesis of the naturally occurring benzopyrans seselin, xanthyletin, precocenes I and II, 8-(3′,3′- dimethylallyl)wenteria chromene, and 2,2-dimethyl-8-prenylchromene-6-propenoic acid. Ph3PAuNTf2 is a general, highly efficient, and product-selective catalyst for the clean synthesis of 2H-chromenes from the cycloisomerization of aryl propargyl ethers.The Ph3PAuNTf 2-catalyzed cyclization was applied as a key step in the synthesis of several benzopyran-bearing naturally occurring substances. Copyright