331456-04-3

Upstream product

• 108-91-8 cyclohexylamine 
• 69875-54-3 2,4-Dichloroquinoline-3-carbonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 246546-72-5 2-Chloro-4-(cyclohexylamino)quinoline-3-carbonitrile 

Relevant academic research and scientific papers

Fused quinoline heterocycles IV: First synthesis of four heterocyclic ring systems of 1H-5-thia-1,2,3,6-tetraazaacephenanthrylenes and 1H-5-thia-1,3,6-triazaacephenanthrylenes

Reaction of 4-alkylamino-2-chloroquinoline-3-carbonitriles 4a-e with an equimolecular amount of ethyl mercaptoacetate gave, in each case, the corresponding ethyl 4-alkylamino-3-aminothieno[2,3-b]quinoline-2-carboxylates 7a-e. Diazotization of 7a-e afforded the novel tetracyclic ring system ethyl 1-alkyl-1H-5-thia-1,2,3,6-tetraazaacephenanthrylene-4-carboxylates 8a-e. Refluxing 7a-e with an excess of triethyl orthoformate yields the new ethyl 1-alkyl-1H-5-thia-1,3,6-triazaacephenanthrylene-4-carboxylates 9a-e. Reacting 9b, c, as example, with an excess of cyclohexylamine (2a) in boiling DMF furnished the corresponding amides 10a, b in good yields.

Fused quinoline heterocycles IV. First synthesis of four heterocyclic ring systems of 1H-5-thia-1,2,3,6-tetraazaacephenanthrylenes and 1H-5-thia-1,3,6-triazaacephenanthrylenes

The synthesis of some novel fused tetracyclic compounds such as 1H-5-thia-1,2,3,6-tetraazaacephenanthrylenes and 1H-5-thia-1,3,6-triazaacephenanthrylenes containing quinoline ring system have been reported.