331472-31-2Relevant academic research and scientific papers
One-Pot Synthesis of 3-Aryl-5-amino-1,2,4-thiadiazoles from Imidates and Thioureas by I2-Mediated Oxidative Construction of the N–S Bond
Chai, Ling,Lai, Zhenzhen,Xia, Qiangqiang,Yuan, Jiangpei,Bian, Qilong,Yu, Mingjian,Zhang, Wenkai,Xu, Yuanqing,Xu, Hao
, p. 4338 - 4344 (2018/08/31)
A simple and practical method for the one-pot synthesis of 3-aryl-5-amino-1,2,4-thiadiazoles from imidates and thioureas has been developed. The protocol proceeds through sequential base-mediated nucleophilic addition-elimination reactions and an I2-mediated oxidative coupling for the N–S bond formation. The approach employes readily available and nontoxic substrates and a simple workup to provide 3-aryl-5-amino-1,2,4-thiadiazoles that have a free or substituted amino group.
