331647-14-4

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 1352717-97-5 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one 
• 1352718-19-4 6-fluoro-3-(4-methoxybenzyl)-2-methyl-8-morpholino-quinazolin-4(3H)-one 
• 1352717-98-6 8-iodo-3-(4-methoxybenzyl)-2-methyl-6-morpholino-quinazolin-4(3H)-one 
• 1352718-20-7 C₂₂H₂₄FN₃O₃ 
• 1352717-99-7 6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-22-9 C₂₃H₂₅FN₄O₃ 
• 1352718-00-3 6-(4-acetylpiperazin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-01-4 1-[8-iodo-3-(4-methoxybenzyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl]-L-prolinamide 
• 1352718-02-5 8-iodo-3-(4-methoxybenzyl)-2-methyl-6-{[2-(morpholin-4-yl)ethyl]amino}quinazolin-4(3H)-one 
• 1352718-03-6 6-[(2,4-dimethoxybenzyl)amino]-8-iodo-3-(4-methoxybenzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-04-7 6-[(2-hydroxyethyl)amino]-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-05-8 6-[(1-hydroxy-2-methylpropan-2-yl)amino]-8-iodo-3-(4-methoxybenzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-08-1 6-(1H-imidazol-1-yl)-8-iodo-3-(4-methoxybenzyl)-2-methylquinazolin-4(3H)-one 
• 1352718-09-2 8-iodo-6-methoxy-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring

The preparation of 6-aminoquinazolin-4(3H)-ones requires the use of platinum-metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful S NAr reaction directly at the unact