33171-13-0

Basic information

• Product Name: L-ARGININE ETHYLESTER MONOHYDROCHLORIDE
• Synonyms: L-ARGININE ETHYLESTER MONOHYDROCHLORIDE;ARGININE ETHYL ESTER HYDROCHLORIDE
• CAS NO: 33171-13-0
• Molecular Formula: C8H19ClN4O2
• Molecular Weight: 238.71506
• Mol File: 33171-13-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-ARGININE ETHYLESTER MONOHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-ARGININE ETHYLESTER MONOHYDROCHLORIDE(33171-13-0)
• EPA Substance Registry System: L-ARGININE ETHYLESTER MONOHYDROCHLORIDE(33171-13-0)

Safety Data

• Hazardous Substances Data: 33171-13-0(Hazardous Substances Data)

Upstream product

• 1119-34-2 L-arginine hydrochloride 
• 64-17-5 ethanol 
• 74-79-3 L-arginine 

Downstream Products

• 60372-77-2 N^α-lauroyl-L-arginine ethyl ester monohydrochloride 

Relevant articles and documents

Rational Design of Cholesterol Derivative for Improved Stability of Paclitaxel Cationic Liposomes

Purpose: This work explores synthesis of novel cholesterol derivative for the preparation of cationic liposomes and its interaction with Paclitaxel (PTX) within liposome membrane using molecular dynamic (MD) simulation and in-vitro studies. Methods: Chole

Preparation process of ethyl lauroyl arginate hydrochloride

The invention discloses a preparation process of ethyl lauroyl arginate hydrochloride. The method comprises the following steps: 1) adding L-arginine hydrochloride into absolute ethyl alcohol, performing stirring, and dropwise adding trimethylchlorosilane to obtain L-arginine ethyl ester hydrochloride; 2) dissolving the L-arginine ethyl ester hydrochloride in absolute ethyl alcohol, and dropwise adding triethylamine and lauroyl chloride respectively to obtain an ethyl lauroyl arginate crude product; 3) mixing the ethyl lauroyl arginate crude product with deionized water and an organic solvent, removing a water phase, performing washing with saturated sodium chloride to obtain a solvent phase, and performing drying by distillation to obtain L-ethyl lauroyl arginate hydrochloride; and 4), stirring the L-ethyl lauroyl arginate hydrochloride with petroleum ether, and performing standing crystallization and suction filtration to obtain ethyl lauroyl arginate hydrochloride. The trimethylsilane is used in the preparation technological process of the ethyl lauroyl arginate hydrochloride, so that the reaction condition is mild, operation is easy, green and environment-friendly effects are achieved, the yield reaches 99% or above, and the product purity reaches 99% or above.

Production and purification process of ethyl lauroyl arginate hydrochloride

The invention discloses a production and purification process of ethyl lauroyl arginate hydrochloride. The process comprises the following steps: step A, esterfying in ethyl alcohol to obtain ethyl arginate dihydrochloride; step B, adding lauroyl chloride into ethyl arginate dihydrochloride in an organic system in the presence of organic alkali, and carrying out condensation to obtain ethyl lauroyl arginate; step C, acidifying ethyl lauroyl arginate into hydrochloride in the organic system, and purifying the product; and step D, carrying out recrystallization and precipitating solid out, and drying the solid to obtain ethyl lauroyl arginate hydrochloride. Through the production and purification process of ethyl lauroyl arginate hydrochloride, the hydrolysis of the product can be effectively avoided; the product is high in stability in industrial production; the mole yield of the product is 97% or higher; the purity of the product is 97% or higher; compared with the existing productiontechnology, the molar yield and the purity of the product are obviously improved.