331714-07-9Relevant academic research and scientific papers
Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin αvβ3
Boger,Goldberg,Silletti,Kessler,Cheresh
, p. 1280 - 1288 (2007/10/03)
The process of new blood vessel growth from existing vasculature, known as angiogenesis, is critical to several pathological conditions, most notably cancer. Both MMP2, which degrades the extracellular matrix (ECM), and integrin αvβ3
