331761-46-7

Basic information

• Product Name: 4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE
• Synonyms: AURORA 20253;BUTTPARK 121\18-49;4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE;OTAVA-BB BB7012780033;THIENO[2,3-D]PYRIMIDINE, 4-CHLORO-5-(4-CHLOROPHENYL)-
• CAS NO: 331761-46-7
• Molecular Formula: C12H6Cl2N2S
• Molecular Weight: 281.16
• Mol File: 331761-46-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 139.5-141℃
• Boiling Point: 443.1 °C at 760 mmHg
• Flash Point: 221.8 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 1.24E-07mmHg at 25°C
• Refractive Index: 1.701
• CAS DataBase Reference: 4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE(331761-46-7)
• EPA Substance Registry System: 4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE(331761-46-7)

Safety Data

• Hazardous Substances Data: 331761-46-7(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDINE is a chemical compound that belongs to the class of thiophene-containing pyrimidine derivatives. It is characterized by the presence of a chlorine atom at the 4th and 4-chlorophenyl group at the 5th position of the thiophene ring. This chemical compound has potential applications in the field of pharmaceuticals, agrochemicals, and material science due to its unique structure and properties. It may possess biological activities and be used as a building block in organic synthesis to develop new drugs and materials. Further research is required to explore its potential uses and applications.

InChI:InChI=1/C12H6Cl2N2S/c13-8-3-1-7(2-4-8)9-5-17-12-10(9)11(14)15-6-16-12/h1-6H

Upstream product

• 13455-81-7 Ethyl 3-(4-chlorophenyl)-2-cyano-2-butenoate 
• 65234-09-5 ethyl 2-amino-4-chlorophenyl-thiophene-3-carboxylate 
• 77287-34-4 formamide 
• 86604-36-6 2-amino-4-(4-chlorophenyl)-3-thiophenecarbonitrile 

Downstream Products

• 329708-99-8 C₁₈H₁₂ClN₃S 
• 670270-49-2 C₁₈H₁₀Cl₂FN₃S 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

Design, synthesis & evaluation of condensed 2H-4-arylaminopyrimidines as novel antifungal agents

A small, focussed library of condensed 2H-4-arylaminopyrimidines, with 3-diversity points, based on an initial design by molecular docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14α

THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS

The present invention provides thienopyrimidine compounds which are potasium channels inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also provided.