331765-80-1Relevant academic research and scientific papers
MUSCARINIC M2 RECEPTOR BLOCKADE TO DELAY OR PREVENT ONSET OF PROGRESSIVE MEMORY DECLINE
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, (2018/10/04)
Provided are methods for delaying or preventing onset of progressive memory decline by administering a muscarinic M2 receptor blocking compound to patients identified as at risk of developing a condition characterized by progressive memory decline, prior
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists
Ting, Pauline C.,Lee, Joe F.,Wu, Jie,Umland, Shelby P.,Aslanian, Robert,Cao, Jianhua,Dong, Youhao,Garlisi, Charles G.,Gilbert, Eric J.,Huang, Ying,Jakway, James,Kelly, Joseph,Liu, Zhidan,McCombie, Stuart,Shah, Himanshu,Tian, Fang,Wan, Yuntao,Shih, Neng-Yang
, p. 1375 - 1378 (2007/10/03)
Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3- hydroxymethyl-1′(6-quinolinylcar
Isopropyl amide derivatives of potent and selective muscarinic M 2 receptor antagonists
Palani, Anandan,Dugar, Sundeep,Clader, John W.,Greenlee, William J.,Ruperto, Vilma,Duffy, Ruth A.,Lachowicz, Jean E.
, p. 1791 - 1794 (2007/10/03)
Low molecular weight amide derivatives were synthesized and evaluated as M2 receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M2 receptor a
Muscarinic M2 antagonists: Anthranilamide derivatives with exceptional selectivity and in vivo activity
Clader, John W.,Billard, William,Binch III, Herbert,Chen, Lian-Yong,Crosby Jr., Gordon,Duffy, Ruth A.,Ford, Jennifer,Kozlowski, Joseph A.,Lachowicz, Jean E.,Li, Shengjian,Liu, Charles,McCombie, Stuart W.,Vice, Susan,Zhou, Gowei,Greenlee, William J.
, p. 319 - 326 (2007/10/03)
Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity.
MUSCARINIC ANTAGONISTS
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Page 23, (2010/02/06)
Amide derivatives of 1,4 di-substituted piperidine compounds of formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein Q and Q are each -CH=, or one of Q and Q is -CH= and the other is -N=; X is -CH2- or (a); Y and Z are -C(R)=, or one of Y and Z is -C(R)= and the other is -N=; R is 1 to 3 substituents selected from H, halogen and alkoxy; R and R are 1 to 3 substituents selected from H, halogen, alkyl and alkoxy; and R and R are H or (C1-C6) alkyl are muscarinic antagonists usuful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed.
