331767-60-3

Upstream product

• 140-75-0 para-fluorobenzylamine 
• 331767-53-4 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid chloride 

Downstream Products

• 348134-15-6 9-[4-(4-quinazolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-14-5 9-[4-(4-quinoxalin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-12-3 9-{4-[4-(5-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-27-0 9-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-13-4 9-{4-[4-(8-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-21-4 9-[4-(cis-2,6-dimethyl-4-quinolin-2-yl-piperazin-1-yl) butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-19-0 9-{4-[4-(6-fluoro-1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-18-9 9-{4-[4-(1-ethyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-17-8 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-16-7 9-[4-(4-benzothiazol-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 331767-51-2 9-{4-[4-(6-methoxy-pyridin-2-yl)-2,6-dimethyl-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide 
• 331767-40-9 9-{4-[4-(6-methyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide 
• 331767-36-3 9-{4-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide 
• 348134-11-2 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 

Relevant academic research and scientific papers

Substituted piperazine derivatives, the preparation thereofand their use as medicaments

The present invention relates to substituted piperazine derivatives of general formula , (I wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.