331839-41-9

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 924848-57-7 8-(4-chlorobenzylidene)-2-amino-6-benzyl-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile 
• 1231767-70-6 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione 
• 1195986-59-4 C₃₆H₂₈Cl₂N₄O 
• 1174000-34-0 2-amino-6-benzyl-8-(4-chlorobenzylidene)-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis and molecular modeling studies of indole-based antitumor agents

Indole-based compounds 30-63 were synthesized by the multi-component 1,3-dipolar cycloaddition reaction of 1-alkyl-3,5-bis(arylidene)-4-piperidones 11-25 with azomethine ylides (generated by the condensation of isatins 26-28 with sarcosine 29). The single crystal X-ray studies of 46 and 48 supported the regio- and stereoselectivity of the reaction. Most of the synthesized spiro-indoles exhibited potent antitumor properties against the HeLa (cervical cancer) cell line through in vitro sulfo-rhodamine-B bioassay, higher than that of cisplatin. Only compound 54 showed bio-potency against the HepG2 (hepatocellular cancer) cell line, comparable to that of doxorubicin hydrochloride (standard reference). 3D-Pharmacophore and 2D-QSAR studies were used to validate the observed biological data and determine the most important parameters controlling activity. The estimated bio-properties from the computational studies showed high approximations to the experimental data.

CURCUMIN ANALOGS AND METHODS OF MAKING AND USING THEREOF

Compounds having Formula I or II, and methods of making and using thereof, are described herein:

Synthesis of green light emitting fused pyrazolinopiperidines - Photophysical and electrochemical studies

We have synthesized the new, green light emitting pyrazolinopiperidines (PyP) derivatives with extended π-conjugation pathway by simple, two step reactions and are characterized using spectral and single crystal X-ray analysis. The electronic properties of PyP were studied using steady state, and time resolved spectral techniques, theoretical and electrochemical methods. PyP derivatives exhibit intense green fluorescence both in the solid and solution state with the quantum yield of 0.29 in acetonitrile. Importantly, PyP shows non-overlapping absorption and emission spectrum with the large Stokes shift value of ～8000 cm-1. Solvent polarity dependent photophysical properties and theoretical HOMO-LUMO calculation reveal that the singlet excited state possesses significant charge transfer character. The substitution of electron donating/withdrawing substituents show negligible or little influence on the photophysical properties except the trifluoromethyl and 2,4-dichloro phenyl substituent. The electrochemical first oxidation potentials were not influenced by the substituent; however the first reduction potential becomes sensitive towards nature and position of the aryl substituent. Further, photophysical properties of PyP become sensitive to the nature of substituent (ortho/para) positions. The enhanced non-radiative decay for the 2,4-dichlorophenyl substituted PyP as compared to 2- and 4-chlorophenyl substituents (by a factor of two and seven times, respectively) emphasize the necessity for multiple electron withdrawing aryl substituents to induce the measurable charge transfer interactions. The enhanced non-radiative rate constant of trifluoromethyl substituent by eight times than methyl substituent is due to the strong intramolecular charge transfer from pyrazoline to styryl moiety. The Royal Society of Chemistry 2013.

An efficient method for synthesis of pyrano[3,2-c]pyridine derivatives under microwave irradiation

(Chemical Equation Presented) A series of pyrano[3,2-c]pyridine derivatives were synthesized via reactions of 3,5-dibenzylidenepiperidin-4-one and malononitrile in N,N-dimethylformamide under microwave irradiation. It is a simple, efficient, and promising

An efficient and chemoselective synthesis of 1,6-naphthyridines and pyrano[3,2-c]pyridines under microwave irradiation

A series of 1,6-naphthyridines and pyrano[3,2-c]pyridines were selectively synthesized via microwave-assisted reactions controlled by the nature of the solvent. This has resulted in an efficient and promising synthetic method for constructing the 1,6-naph