33184-68-8

Upstream product

• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 191991-32-9 N-(4-dimethylamino-benzyl)-N-methyl-hydroxylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 78848-04-1 4-(Dimethylamino)-N¹-methyl-N²-ethylbenzamidinyl-N¹-oxid 
• 1075227-30-3 C₄₅H₅₀N₂O₆ 
• 1075227-12-1 C₄₅H₅₀N₂O₆ 
• 78848-03-0 4-(Dimethylamino)-N¹,N²-dimethylbenzamidinyl-N¹-oxid 
• 82044-41-5 N,N-dimethyl-4-(2t-methyl-oxaziridin-3r-yl)-aniline 
• 33184-77-9 3t-(4-dimethylamino-phenyl)-2-methyl-5-oxo-isoxazolidine-4r-carboxylic acid methyl ester 
• 71504-35-3 3-(4-dimethylamino-phenyl)-2,4,4-trimethyl-isoxazolidin-5-one 

Relevant academic research and scientific papers

An Efficient Method for the Generation of N-Methylnitrones

N-methylnitrones can be generated in good-to-excellent yields from aldehydes and ketones with a stoichiometric amount of N-methyl-N,O-bis(trimethylsilyl)hydroxylamine under very mild conditions and their formation, involving a bimolecular push-pull type mechanism, is discussed.

Fast method for synthesis of alkyl and aryl-N-methylnitrones

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydr

Oxidation of N-benzyl-N-methylhydroxylamines to nitrones. A mechanistic study

Oxidation of various N-(o-, m-, p- substituted benzyl)- N-methylhydroxylamines has been carried out using mercury(II) oxide and p-benzoquinone (p-BQ) as oxidants. Hammett plots have been obtained with negative ρ values, showing the development of a positive centre in the transition state. The unstable E nitrones, which readily isomerize to the more stable Z nitrones, are obtained in appreciable quantities and in some cases as the major product. A considerable deuterium isotope effect is observed in the oxidation process. The overall picture of the mechanistic pathway involves electron transfer from nitrogen to the oxidant followed by hydrogen abstraction.

Chromium and Tungsten Pentacarbonyl Groups as Reactivity and Selectivity Auxiliaries in Cycloaddition of Alkynyl Fischer Carbene Complexes with N-Alkyl Nitrones

Alkynyl Fischer carbene complexes were found to undergo chemoselective, regioselective, and rate-enhanced 1,3-dipolar cycloaddition with nitrones to give 2,3-dihydroisoxazole carbene complexes in excellent yields.These alkynyl complexes can serve as synth