33189-65-0Relevant articles and documents
Ethylenediamine derivatives useful in treating sickle cell anemia
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, (2008/06/13)
Compounds of the following general formula are useful in the treatment of sickle cell anemia: STR1 WHEREIN EACH OF R and R1 is hydrogen, chlorine, fluorine, bromine, trifluoromethyl, hydroxy, a lower alkoxy group of from 1 to 4 carbon atoms or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; R2 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; R3 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or when R2 is hydrogen, R3 is β,β,β-trichloroethoxycarbonyl, benzyloxycarbonyl, p-methoxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl or tert-butoxycarbonyl; or NR2 R3 taken together form a monocyclic heterocyclic group selected from the group consisting of pyrrolidino, piperidino, morpholino, and N-(lower)alkylpiperazino; Z is STR2 wherein R4 is hydrogen or lower alkyl of from 1 to 4 carbon atoms, and R5 is hydroxy or alkylcarbonyloxy wherein the alkyl moiety has from 1 to 4 carbon atoms; each of m and m' is the integer 1 or 2; n is an integer of from 2 to 6; p is an integer of from 1 to 3; and q is an integer of from zero to 2; or pharmaceutically acceptable acid addition salts and individual optical isomers thereof.