3319-04-8

Basic information

• Product Name: 2-(piperidin-1-yl)cyclohexan-1-one
• Synonyms: 2-(piperidin-1-yl)cyclohexan-1-one;2-(1-Piperidinyl)cyclohexanone;2-(Piperidin-1-yl)cyclohexanone;2-Piperidinocyclohexanone;Einecs 222-017-4
• CAS NO: 3319-04-8
• Molecular Formula: C₁₁H₁₉NO
• Molecular Weight: 181.27466
• EINECS: 222-017-4
• Mol File: 3319-04-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 278.9°Cat760mmHg
• Flash Point: 114.4°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 0.00414mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 2-(piperidin-1-yl)cyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperidin-1-yl)cyclohexan-1-one(3319-04-8)
• EPA Substance Registry System: 2-(piperidin-1-yl)cyclohexan-1-one(3319-04-8)

Safety Data

• Hazardous Substances Data: 3319-04-8(Hazardous Substances Data)

Usage

General Description

2-(piperidin-1-yl)cyclohexan-1-one, also known as PCH, is a chemical compound with the molecular formula C11H19NO. It is a cyclic ketone that contains a piperidine ring, which gives it unique chemical properties. PCH is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical compounds. It can also be used as a reagent in organic synthesis and as a precursor for the production of other chemical compounds. Additionally, PCH has potential applications in medical research, particularly in the development of new medications for the treatment of various neurological and psychiatric disorders.

InChI:InChI=1/C11H19NO/c13-11-7-3-2-6-10(11)12-8-4-1-5-9-12/h10H,1-9H2

Upstream product

• 110-89-4 piperidine 
• 822-87-7 2-Chlorocyclohexanone 
• 533-60-8 cyclohexanone-2-ol 
• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 
• 108-94-1 cyclohexanone 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 

Downstream Products

• 118207-35-5 1-(1-pyrrolidino)-6-(1-piperidino)cyclohex-1-ene 
• 882409-09-8 (1S,2R)-2-(piperidin-1-yl)cyclohexanol 
• 118207-31-1 cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane 
• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 
• 7581-94-4 (+/-)-cis-2-Piperidino-cyclohexanol 
• 94824-44-9 1-phenyl-2-piperidin-1-yl-cyclohexanol 

Relevant articles and documents

Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation

(Chemical Equation Presented) Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(-)-50488 based on this reaction is reported.

Studies on the Oxidation of Enamines with Molecular Oxygen. I. Oxidation of Some Piperidino Alkenes

In the autoxidation of 1-piperidinocyclohex-1-ene (1), 1-piperidinobut-1-ene (2), 3-piperidinopent-2-ene (3), and 1-piperidino-2-methyl-prop-1-ene (4) only products of an oxidative attack at the C=C-double bond are formed.Both α-aminoketones, the products of the rearrangement of primarily formed epoxides, and products of the oxidative scission of the C=C double bond are obtained.As a side reaction some hydrolysis of the starting enamines takes place.This hydrolysis proves that some water must be formed during the enamine oxidation.