3319-04-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(piperidin-1-yl)cyclohexan-1-one is used as a building block for the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure allows for the creation of a wide range of medications with different therapeutic properties.
Used in Organic Synthesis:
2-(piperidin-1-yl)cyclohexan-1-one is used as a reagent in organic synthesis, contributing to the formation of complex molecules and compounds. Its presence in reactions can lead to the development of new chemical entities with potential applications in various industries.
Used in Chemical Production:
2-(piperidin-1-yl)cyclohexan-1-one is used as a precursor for the production of other chemical compounds. Its role in the synthesis process is crucial for obtaining desired end products with specific properties and functions.
Used in Medical Research:
2-(piperidin-1-yl)cyclohexan-1-one has potential applications in medical research, particularly in the development of new medications for the treatment of various neurological and psychiatric disorders. Its unique structure may offer new avenues for therapeutic intervention and drug discovery.

InChI:InChI=1/C11H19NO/c13-11-7-3-2-6-10(11)12-8-4-1-5-9-12/h10H,1-9H2

Upstream product

• 110-89-4 piperidine 
• 822-87-7 2-Chlorocyclohexanone 
• 533-60-8 cyclohexanone-2-ol 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 108-94-1 cyclohexanone 
• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 

Downstream Products

• 94824-44-9 1-phenyl-2-piperidin-1-yl-cyclohexanol 
• 7581-94-4 (+/-)-cis-2-Piperidino-cyclohexanol 
• 118207-35-5 1-(1-pyrrolidino)-6-(1-piperidino)cyclohex-1-ene 
• 118207-31-1 cis-1-(1-piperidino)-2-(1-pyrrolidino)cyclohexane 
• 882409-09-8 (1S,2R)-2-(piperidin-1-yl)cyclohexanol 
• 7581-94-4 (+)-trans-(1-Piperidyl)cyclohexan-2-ol 

Relevant academic research and scientific papers

Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation

(Chemical Equation Presented) Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(-)-50488 based on this reaction is reported.

Studies on the Oxidation of Enamines with Molecular Oxygen. I. Oxidation of Some Piperidino Alkenes

In the autoxidation of 1-piperidinocyclohex-1-ene (1), 1-piperidinobut-1-ene (2), 3-piperidinopent-2-ene (3), and 1-piperidino-2-methyl-prop-1-ene (4) only products of an oxidative attack at the C=C-double bond are formed.Both α-aminoketones, the products of the rearrangement of primarily formed epoxides, and products of the oxidative scission of the C=C double bond are obtained.As a side reaction some hydrolysis of the starting enamines takes place.This hydrolysis proves that some water must be formed during the enamine oxidation.

Efficient Preparation of Cis Vicinal Tertiary Diamines from 2-Hydroxy Ketones in Two Steps

Cyclic (C5 and C6) cis vicinal tertiary diamines are efficiently prepared by catalytic hydrogenation, Pd(C), of the corresponding N-substituted amino enamines, e.g. 6.The latter are obtained by p-toluenesulfonic acid catalyzed condensation of secondary amines with cyclic 2-hydroxy ketones in refluxing benzene under Dean-Stark conditions or from the N-substituted 2-amino ketones.For example cis-1,2-dipyrrolidinocyclohexane has been obtained from adipoin in 69percent overall yield, isolated.