331947-69-4

Basic information

• Product Name: Benzoyl chloride, 2-methyl-4-[(2-methylbenzoyl)amino]-
• CAS NO: 331947-69-4
• Molecular Formula: C16H14ClNO2
• Molecular Weight: 287.746
• Mol File: 331947-69-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-methyl-4-[(2-methylbenzoyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-methyl-4-[(2-methylbenzoyl)amino]-(331947-69-4)
• EPA Substance Registry System: Benzoyl chloride, 2-methyl-4-[(2-methylbenzoyl)amino]-(331947-69-4)

Safety Data

• Hazardous Substances Data: 331947-69-4(Hazardous Substances Data)

Upstream product

• 317374-08-6 2-methyl-4-(2-methylbenzoylamino)benzoic acid 

Downstream Products

• 926035-31-6 (4S,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 926035-32-7 (4S,5R)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 926035-33-8 (4R,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 150683-30-0 tolvaptan 
• 137973-76-3 MOP-21826 
• 1296212-28-6 N-(4-(7-chloro-2,3-dihydro-5-oxo-2,2,4,4-tetradeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 
• 1296212-20-8 N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 
• 1296212-27-5 N-(4-(7-chloro-5-oxo-2,2-dideutero-3,4-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 
• 1296212-19-5 N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 
• 1296212-26-4 N-(4-(5-(tert-butyldimethylsilyloxy)-7-chloro-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 
• 331947-63-8 (R)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 331947-57-0 (S)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

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MANUFACTURING METHOD OF TOLVAPTAN, SALT THEREOF AND SOLVATE

PROBLEM TO BE SOLVED: To provide a manufacturing method of high purity and high yield tolvaptan, a salt thereof, or a solvate thereof without using a solvent with large environmental load, and having enhanced operability of a reaction. SOLUTION: There is provided a manufacturing method of tolvaptan, a salt thereof, or a solvate thereof, including a process for reacting following a described carboxylic acid derivative (I) with a chlorination agent such as thionyl chloride to convert it to a corresponding acid chloride (I), in which the reaction process is conducted in a presence of a solvent having relative dielectric constant of 10 or more and donor number of 20 or more, and represented by N,N-dimethyl acetamide, N-methyl-2-pyrrolidone, N.N'-dimethyl propylene urea or N,N,N',N'-tetramethyl urea. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT