331980-15-5Relevant academic research and scientific papers
Synthesis of some new pyrimidine bases as precursors of potential anticancer nucleosides
Sharma, Anoop K.,Yadav, Ashok K.,Prakash, Lalit
, p. 740 - 742 (2007/10/03)
3,5,7-Trisubstituted-pyridopyrimidine-2,4(1H,3H)-diones (4) have been synthesized from the reaction of 2-amino-3-cyano-4,6-diarylpyridines (2) with arylisocyanates in dioxan-pyridine.Compounds 4 have also been prepared by the hydrolysis of 2 with alc.KOH to give 2-amino-3-carboxamido-4,6-disubstituted pyridines (3) which on refluxing with arylisocyanate in diphenyl ether afford 4.They are characterised by elemental analyses and IR and 1H NMR spectral data.They have been tested for antibacterial and antifungal activity.
