331980-93-9Relevant academic research and scientific papers
The conformational behaviour of fucosyl and carbafucosyl mimetics in the free and in the protein-bound states
Carpintero, Mercedes,Fernandez-Mayoralas, Alfonso,Jimenez-Barbero, Jesus
, p. 681 - 689 (2007/10/03)
The conformational behaviours of fucosyl glycosides bearing a glyceryl aglycon and their corresponding carbafucosyl glycomimetics have been studied both in aqueous solution and when bound to a fucose-specific lectin (Aurelia Aurantia Agglutinnin), using a combination of NMR spectroscopy (J and NOE data) and molecular mechanics calculations. Analogies and differences between the mimetics and the natural compounds have been found.
