331986-99-3Relevant academic research and scientific papers
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
Williams, Richard,Johnson, Kari A.,Gentry, Patrick R.,Niswender, Colleen M.,Weaver, Charles D.,Conn, P. Jeffrey,Lindsley, Craig W.,Hopkins, Corey R.
scheme or table, p. 4967 - 4970 (2010/03/24)
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
The crucial role of the nitrogen substituent in the desymmetrisation of cyclic meso-imides using B-Me and B-OMe oxazaborolidine catalysts
Barker, Mike D.,Dixon, Rachel A.,Jones, Simon,Marsh, Barrie J.
, p. 11663 - 11669 (2007/10/03)
Various cyclic meso-imides have been desymmetrised via enantioselective reduction using two chiral oxazaborolidine catalysts derived from (1R,2S)-cis-1-amino-indan-2-ol followed by the reduction of the hydroxylactam product to give the γ-lactam. The enant
