33207-69-1

Usage

Chemical structure

A pyrrole ring with two methyl groups at positions 1 and 3, and a carboxylic acid functional group at position 2

Functional groups

Carboxylic acid, pyrrole, and methyl groups

Derivative of

Pyrrole

Applications

a. Building block in organic synthesis and medicinal chemistry
b. Preparation of pharmaceuticals and biologically active compounds
c. Potential therapeutic applications in cancer and neurodegenerative disorders treatment
d. Intermediate in the synthesis of natural products and complex organic molecules

Physical properties

Not provided in the material

Chemical properties

Not provided in the material

Reactivity

Not provided in the material

Solubility

Not provided in the material

Upstream product

• 33207-68-0 ethyl 1,3-dimethyl-1H-pyrrole-2-carboxylate 
• 40611-69-6 methyl 3-methyl-1H-pyrrole-2-carboxylate 

Downstream Products

• 1041644-30-7 C₁₄H₁₄ClFN₂O 

Relevant academic research and scientific papers

Heterocyclic acylamide derivative and preparation method and pharmaceutical application thereof

The invention relates to a heterocyclic acylamide derivative and a preparation method and pharmaceutical application thereof, in particular to a heterocyclic acylamide derivative shown as a general formula (I) or a stereoisomer and a pharmaceutically-acce

HETEROCYCLIC INHIBITORS OF NECROPTOSIS

The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induce

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.