332079-08-0

Basic information

• Product Name: Phosphoric acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester
• CAS NO: 332079-08-0
• Molecular Weight: 620.558
• Mol File: 332079-08-0.mol

Chemical Properties

• CAS DataBase Reference: Phosphoric acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester(332079-08-0)
• EPA Substance Registry System: Phosphoric acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester(332079-08-0)

Safety Data

• Hazardous Substances Data: 332079-08-0(Hazardous Substances Data)

Upstream product

• 239100-12-0 N⁶-(1-naphthalenemethyl)-2'-deoxy-2'-(3-methoxybenzamido)adenosine 

Downstream Products

• 332079-09-1 Morpholin-4-yl-phosphonic acid mono-((2R,3S,4R,5R)-3-hydroxy-4-(3-methoxy-benzoylamino)-5-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl) ester 

Relevant articles and documents

A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase

N6-Naphthalenemethyl-2′-methoxybenzamido-β-NAD +, a derivative of a low micromolar first-generation inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH), was synthesized, taking advantage of methodology for the selective phosphitylation of nucleosides. The compound was found to be a poor alternate cosubstrate for GAPDH, but an extremely potent inhibitor. Although intended for use in crystallization trials, the analogue presents possibilities for further drug design.