33211-98-2Relevant academic research and scientific papers
Synthesis, characterization, spectroscopy, cytotoxic activity and molecular dynamic study on the interaction of three palladium complexes of phenanthroline and glycine derivatives with calf thymus DNA
Ajloo, Davood,Eslami Moghadam, Mahboube,Ghadimi, Khadijeh,Ghadamgahi, Maryam,Saboury, Ali Akbar,Divsalar, Adeleh,Sheikhmohammadi, Minoo,Yousefi, Khalil
, p. 144 - 160 (2015/03/31)
The interaction of three novel synthesized complexes of [Pd(phen)(R-gly)]NO3, where R-gly is methyl-, propyl-, and amyl-glycine; and phen is 1,10-phenanthroline were synthesized and characterized by spectroscopic methods. The interaction of ct-
Inactivation of Monoamine Oxidase B by Analogues of the Anticonvulsant Agent Milacemide (2-(n-Pentylamino)acetamide)
Nishimura, Kuniko,Lu, Xingliang,Silverman, Richard B.
, p. 446 - 448 (2007/10/02)
Analogues of the anticonvulsant agent milacemide (1, 2-(n-pentylamino)acetamide), in which the carboxamide group is changed to a nitrile (2), a carbethoxy group (3), a carboxylic acid (4), a cyanomethyl group (5), and a trifluoromethyl group (6), were synthesized and tested as substrates and inactivators of monoamine oxidase B (MAO B).The carboxylic acid was neither a substrate nor an inactivator.The trifluoromethyl compound was not soluble in buffer even when organic cosolvents were added, so it could not be tested.All of the other compounds were both substrates and time-dependent irreversible inactivators of MAO B.A plot of the logarithm of kcat/kinact (a measure of the efficiency of the inactivators) versus ?I (Figure 1) shows a linear free energy relationship between the inactivator efficiency and the electron-withdrawing ability of the substituent.As the electron-withdrawing ability increases, the partition ratio decreases indicating that inactivation is becoming more efficient relative to substrate turnover to product.Milacemide was the least efficient of the compounds tested; the nitrile 2 was the most efficient.
