332113-78-7

Upstream product

• 288-47-1 1,3-thiazole 
• 106-38-7 para-bromotoluene 
• 127118-89-2 C₁₁H₁₁NO₃ 
• 624-31-7 4-tolyl iodide 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 6071-54-1 5-(4-methylphenyl)-2-phenylthiazole 
• 4271-09-4 2,2'-benzothiazolyl 
• 1398308-29-6 2-(5-(p-tolyl)thiazol-2-yl)benzo[d]thiazole 
• 1388625-47-5 2-(5-p-tolylthiazol-2-yl)benzoxazole 
• 1339019-86-1 (E)-2-(oct-4-en-4-yl)-5-(4-tolyl)thiazole 
• 882182-72-1 2-phenylsulfanyl-5-p-tolyl-thiazole 

Relevant academic research and scientific papers

Colourless p-phenylene-spaced bis-azoles for luminescent concentrators

We report on the synthesis of new push-pull imidazole-benzothiazole and thiazole-benzothiazole fluorophores obtained in good yields by using direct C-H arylation synthetic strategies. Spectroscopic investigations in CHCl3 solution evidenced that the 1,4-phenylene-spaced imidazole-benzothiazole bearing an electron-donating dimethylamino group achieved a trade-off between fluorescence maximum (516 nm), Stokes shift (165 nm) and a quantum yield higher than 0.4. Dispersions of the selected fluorophore in poly (methyl methacrylate) (PMMA) thin films mostly maintained the optical features in solution with significant light transmittance in the visible region (90% at 440 nm), and a brilliant green emission at 500 nm. Photocurrent experiments performed on PMMA thin films coated over high purity transparent glasses promoted their use in the development of colourless luminescent solar concentrators with optical efficiencies close to 6%.

Mild palladium-catalyzed regioselective direct arylation of azoles promoted by tetrabutylammonium acetate

A mild, general, and convenient palladium-catalyzed direct arylation of the 5-position of azoles with aryl bromides, efficiently promoted by tetrabutylammonium acetate, is described. 1-Methylpyrazole, oxazole, and thiazole reacted at 70°C in N,N-dimethyla

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

Facile generation of a library of 5-aryl-2-arylsulfonyl-1,3-thiazoles

Treatment of N,N-diformylaminomethyl aryl ketones with phosphorus pentasulfide/triethylamine in chloroform gives 5-arylthiazoles directly in good yield. The 5-aryl-1,3-thiazole core has been successfully functionalised at the 2-position to yield, over two

Direct arylation reactions catalyzed by Pd(OH)2/C: Evidence for a soluble palladium catalyst

Palladium hydroxide on carbon (Pearlman's catalyst) effectively catalyzes direct arylation reactions of aryl iodides and bromides, providing excellent arylation-to-hydrodehalogenation ratios (>30:1) with broad scope for both intra- and intermolecular arylation processes. Studies aimed at determining the nature of the active catalyst indicate that an active homogeneous palladium species is produced under the reaction conditions.

Preparation of 2- and 5-aryl substituted thiazoles via palladium-catalyzed Negishi cross-coupling

2-Aryl substituted thiazoles 3a-k were prepared by oxidative insertion of zinc into 2-bromothiazole (1) followed by palladium(0)-catalyzed Negishi cross-coupling in a one-pot procedure. 5-Aryl substituted thiazoles 6a-i were prepared by regioselective C-5 lithiation of 2-(trimethylsilyl)thiazole (4) followed by transmetalation with zinc chloride and palladium(0)-catalyzed Negishi cross-coupling in a one-pot procedure. The synthetic sequences were combined to give 2,5-diaryl substituted thiazoles 8a,b and 10 via stepwise C-2 and C-5 arylation and vice versa.