33216-38-5Relevant academic research and scientific papers
A Short synthesis of benzomorphane analgesics (±)-Metazocine and (±)-Phenazocine
Singh, Kamal Nain,Singh, Pushpinder,Sharma, Arvind Kumar,Singh, Paramjit,Kessar, Satinder V.
experimental part, p. 3716 - 3720 (2010/12/29)
A three step synthesis of (±)-metazocine and (±)-phenazocine starting with 3,4-lutidine is described. The key step involves Lewis acid promoted lithiation/electrophilic substitution reaction of N-alkyl-3,4-dimethyl- 1,2,5,6- tetrahydropyridine. Copyright
Lewis Acid Complexed Heteroatom Carbanions; A New Concept for α-Metallation of Tertiary Amines
Kessar, Satinder V.,Singh, Paramjit,Vohra, Rahul,Kaur, Nachhattar Pal,Singh, Kamal Nain
, p. 568 - 570 (2007/10/02)
BF3 complexes of typical benzylic, allylic and saturated N-methyl tertiary amines were α-lithiated, with lithium tetramethylpiperidide (LTMP) or sec-butyllithium, and were treated with electrophiles.
