332167-71-2Relevant academic research and scientific papers
Carboxyl activation via silylthioesterification: One-pot, two-step amidation of carboxylic acids catalyzed by non-metal ammonium salts
Lamar, Angus A.,Liebeskind, Lanny S.
supporting information, p. 6034 - 6037 (2015/10/28)
The first organo-catalyzed silylthioesterification of a carboxylic acid and a commercially available mercaptoorganosilane results in the in situ production of an O-silylthionoester. Subsequent amine addition forms amides in an operationally simple one-pot procedure without removal of water. The scope and efficiency of these reactions with respect to the catalyst, carboxylic acid, amine, [Si-S] moiety, and solvent are investigated. A number of functionalities are tolerated in the two-step amidation including alkene, alkyne, alkyl and aryl halides, benzylic ethers, and heterocycles with free coordinating sites.
Synthesis and biological evaluation of new niphathesine analogues
Krauss, Juergen,Wetzel, Christine,Thiel, Julia,Neudert, Christine,Bracher, Franz
, p. 154 - 158 (2008/02/05)
Niphathesine C and related pyridine alkaloids are well known natural products with interesting antimicrobial activities, characterized by a pyridine ring and a lipophilic side chain with a terminal nitrogen-containing functional group. This paper describe
