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• 55-21-0 benzamide 
• 89-98-5 2-chloro-benzaldehyde 
• 135-19-3 β-naphthol 

Relevant academic research and scientific papers

2-Hydroxy-5-sulfobenzoic acid: An efficient organocatalyst for the three-component synthesis of 1-amidoalkyl-2-naphthols and 3,4-disubstituted isoxazol-5(4H)-ones

2-Hydroxy-5-sulfobenzoic acid (2-HSBA) efficiently catalyzed the one-pot three-component synthesis of a wide variety of 1-amidoalkyl-2-naphthols and 3,4-disubstituted isoxazol-5(4H)-ones. The three-component process of substituted benzaldehydes, 2-naphthol, and amides (benzamide and acetamide) or urea occur using 10 mol% of 2-HSBA as an organocatalyst under solvent-free reaction conditions (SFRCs) at 100 °C. It was also found that the best results for the preparation of 3,4-disubstituted isoxazol-5(4H)-ones were achieved using 15 mol% of 2-HSBA under aqueous conditions at room temperature. The reactions are easy to do and were completed within 3-25 min (for amidoalkyl naphthols), and 70-120 min (for 3,4-disubstituted isoxazol-5(4H)-ones), while the expected products were obtained in 82-97 % yields. The catalyst can be recovered and reused several times in the template reactions. This procedure offers the advantages of convenience, simple operational procedure, cost-effectiveness, no use of hazardous organic solvents, and the commercial availability of the catalyst.

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

Amidoalkyl derivatives are significant compounds due to their application in the preparation of potent drugs and important biological compounds. In this context, we presented a new method for the synthesis of amido alkyl β-naphthol and amidoalky naphthoqu

Solvent-free synthesis of 1-amidoalkyl-2-naphthols using magnetic nanoparticle-supported?2-(((4-(1-iminoethyl)phenyl)imino)methyl)phenol Cu (II) or Zn (II) Schiff base complexes

Two magnetic nanoparticle-supported?2-(((4-(1-iminoethyl)phenyl)imino)methyl)phenols were successfully synthesized, characterized, and applied in the one-pot three-component reaction of substituted benzaldehydes, 2-naphthol, and amides for synthesis of 1-

Solvent-free synthesis of amidoalkyl naphthols in the presence of MWCNTs@SiO2/SO3H as effective solid acid catalyst

Abstract: Multiwalled carbon nanotubes (MWCNTs) were modified with sulfonic acid groups through a new method. In the first step, MWCNTs’ surfaces were hydroxylated using KMNO4 as oxidating agent and a surfactant (TPABr). Second, SiO2

Sulfonated polynaphthalene as an effective and reusable catalyst for the one-pot preparation of amidoalkyl naphthols: DFT and spectroscopic studies

Sulfonated polynaphthalene (S-PNP) as a carbon-based solid acid efficiently catalyzed the one-pot three-component synthesis of amidoalkyl naphthols. The three-component process of substituted aryl aldehydes, 2-naphthol, and amide (benzamide and acetamide)

Simple hydrothermal synthesis of sphere-like TiO2 nanoparticles and their functionalization with 1,4-butane sultone as a new heterogeneous catalyst

Abstract: For the first time, anatase TiO2 nanoparticles with high specific surface area have been synthesized by hydrothermal method using titanium (IV) ethoxide solution. Nanocrystalline titania-based sulfonic acid (nano-TiO2–Bu–SO

Homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H) as an efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols

Mesoporous silica nanoparticles are efficiently functionalized with homopiperazine sulfamic acid. The resulting MSNs-HPZ-SO3H is employed as a nanocatalyst in one-pot synthesis of 1-amidoalkyl-2-naphthols, through three-component condensation r

Aluminatesulfonic acid: Novel and recyclable nanocatalyst for efficient synthesis of aminoalkyl naphthols and amidoalkyl naphthols

In this study, an efficient, mild, and eco-friendly procedure is developed for the preparation of 1-amidoalkyl-2-naphthols and Betti bases from one-pot three-component condensation of aldehydes, 2-naphthol, and nitrogen sources (amides for amidoalkyl naphthols and amine for Betti bases) in the presence of aluminatesulfonic acid nanoparticles (ASA NPs) as recoverable catalyst under solvent-free conditions. ASA NPs were prepared by a simple reaction of net chlorosulfonic acid and sodium aluminate in high purity. ASA NPs were characterized by Fourier transform IR, X-ray powder diffraction, transmission electron microscopy, energy-dispersive X-ray, thermal gravimetric analysis, and UV diffusion/reflectance techniques. On the basis of the thermal gravimetric analysis and some activation parameters evaluated from decomposition thermal steps using Coats–Redfern model, the catalyst showed high thermal stability. High yields, short reaction time, easy workup, inexpensive, and reusability of the catalyst are advantages of this method.

Ecofriendly and efficient multicomponent method for preparation of 1-amidoalkyl-2-naphthols using maltose under solvent-free conditions

An efficient and entirely green protocol for preparation of 1-amidoalkyl-2-naphthols employing a multicomponent one-pot condensation reaction of 2-naphthol, amides or urea, and aromatic aldehydes in the presence of maltose under solvent-free conditions is