33224-88-3Relevant academic research and scientific papers
Secondary amines and use in pharmaceutical compositions
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, (2008/06/13)
A compound of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula STR2 wherein R1 is hydrogen or fluorine, R2 is hydrogen, C1-6 alkyl, halogen or trifluoromethyl; or W is a phenoxymethyl or benzofuran-2-yl group; R3 is C1-12 alkyl or phenyl C1-6 alkyl; A is hydrogen or methyl, X is carboxy, --Z--CO2 H, --Z--OH, T--Z--CO2 H, --Z--NR4 R5, --T--Y--OM, --T--Y--NR4 R5, or --T--R6, in the para- or meta-position with respect to the --(CH2)n group, wherein R4 and R5 are each hydrogen or C1-6 alkyl, R6 is C1-6 alkyl, T is 0, S, --NH or --N--R7, in which R7 is C1-6 alkyl Z is C1-10 straight or branched alkylene optionally containing a carbon-carbon double bond; Y is C2-10 straight or branched alkylene, provided that the hetero atoms in --T--Y--OM and --T--Y--NR4 R5 are separated by at least two carbon atoms, M is hydrogen, C1-6 alkyl or phenyl, and n is 1 or 2, is useful for obesity or hyperglycaemia.
