3323-02-2

Basic information

• Product Name: 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine
• Synonyms: 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine
• CAS NO: 3323-02-2
• Molecular Formula: C₁₉H₂₁N₃O₂
• Molecular Weight: 323.39
• Mol File: 3323-02-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.23g/cm³
• Refractive Index: 1.629
• CAS DataBase Reference: 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine(3323-02-2)
• EPA Substance Registry System: 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine(3323-02-2)

Safety Data

• Hazardous Substances Data: 3323-02-2(Hazardous Substances Data)

Usage

General Description

The chemical "2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine" is an imidazopyridine derivative that contains a p-methoxyphenyl group and a morpholinomethyl group. It belongs to the class of organic compounds known as imidazopyridines. This chemical has potential pharmacological properties and may be used in the development of new drugs or as a research tool in pharmacology. It is important to handle this chemical with care and to follow proper safety protocols as it may have hazardous properties.

InChI:InChI=1/C19H21N3O2/c1-23-16-7-5-15(6-8-16)19-17(14-21-10-12-24-13-11-21)22-9-3-2-4-18(22)20-19/h2-9H,10-14H2,1H3

Upstream product

• 504-29-0 2-aminopyridine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 31562-99-9 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine 
• 110-91-8 morpholine 
• 298-12-4 Glyoxilic acid 
• 50-00-0 formaldehyd 

Relevant articles and documents

Use of imidazo[1,2-a]pyridine as a carbonyl surrogate in a mannich-like, catalyst free, one-pot reaction

Derivatization of imidazo[1,2-a]pyridine scaffolds have gained considerable attention due to the biological significance of therapeutics based on the imidazopyridine core. By utilizing a catalyst-free, “Mannich type” reaction, we developed a simple and efficient protocol to aminomethylate the C-3 position of imidazo[1,2-a]pyridine through a multicomponent, de-carboxylation reaction involving imidazo[1,2-a]pyridine, a secondary amine, and glyoxylic acid. The developed protocol re-quires mild reaction conditions and furnishes diverse imid-azo[1,2-a]pyridine analogues from commercially available starting materials. Additionally, the current protocol improves prior methods, which were limited by the amine substrate scope. Taken together, this current methodology permits rapid diversification of imidazo[1,2-a]pyridines to enhance combinatorial efficiency in the drug discovery processes.