33237-73-9

Usage

Uses

Used in Organic Synthesis:
(2,3-dihydro-1H-inden-2-yl)(phenyl)ammonium chloride is used as a quaternary ammonium catalyst for facilitating various chemical reactions. Its application is particularly beneficial in the synthesis of pharmaceuticals and other organic compounds, enhancing the efficiency and selectivity of these processes.
Used in Chemical Research:
As a quaternary ammonium catalyst, (2,3-dihydro-1H-inden-2-yl)(phenyl)ammonium chloride is also utilized in chemical research to study and develop new reaction pathways and mechanisms, contributing to the advancement of synthetic chemistry.
Used in Polymer Chemistry:
(2,3-dihydro-1H-inden-2-yl)(phenyl)ammonium chloride serves as a stabilizer in polymer chemistry, helping to control the polymerization process and improve the properties of the resulting polymers.
Used in Chemical Production:
(2,3-dihydro-1H-inden-2-yl)(phenyl)ammonium chloride acts as an intermediate in the production of other chemicals, playing a crucial role in the synthesis of a variety of chemical products.
Used in Medicinal Chemistry:
Due to its potential biological activity, (2,3-dihydro-1H-inden-2-yl)(phenyl)ammonium chloride is being investigated for its possible applications in medicinal chemistry, where it may contribute to the development of new therapeutic agents.

InChI:InChI=1/C15H15N.ClH/c1-2-8-14(9-3-1)16-15-10-12-6-4-5-7-13(12)11-15;/h1-9,15-16H,10-11H2;1H

Upstream product

• 62-53-3 aniline 
• 615-13-4 2-indanone 

Relevant academic research and scientific papers

Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures

Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the reaction includes aliphatic acyclic and cyclic ketones, aliphatic and aromatic aldehydes, and primary and secondary amines including a variety of weakly basic and nonbasic amines. Limitations include reactions with aromatic and unsaturated ketones and some sterically hindered ketones and amines. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran (THF) and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions, but it is generally not needed with aldehydes. The procedure is carried out effectively in the presence of acid sensitive functional groups such as acetals and ketals; it can also be carried out in the presence of reducible functional groups such as C-C multiple bonds and cyano and nitro groups. Reactions are generally faster in DCE than in THF, and in both solvents, reactions are faster in the presence of AcOH. In comparison with other reductive amination procedures such as NaBH3CN/MeOH, borane-pyridine, and catalytic hydrogenation, NaBH(OAc)3 gave consistently higher yields and fewer side products. In the reductive amination of some aldehydes with primary amines where dialkylation is a problem we adopted a stepwise procedure involving imine formation in MeOH followed by reduction with NaBH4.