33238-32-3

Basic information

• Product Name: 2-(2-methyl-5-nitrophenyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-isoindole-1,3(2H)-dione, 2-(2-methyl-5-nitrophenyl)-
• CAS NO: 33238-32-3
• Molecular Formula: C₁₅H₁₀N₂O₄
• Molecular Weight: 282.2509
• Mol File: 33238-32-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 490.5°C at 760 mmHg
• Flash Point: 250.4°C
• Density: 1.448g/cm³
• Vapor Pressure: 9.13E-10mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 2-(2-methyl-5-nitrophenyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-5-nitrophenyl)-1H-isoindole-1,3(2H)-dione(33238-32-3)
• EPA Substance Registry System: 2-(2-methyl-5-nitrophenyl)-1H-isoindole-1,3(2H)-dione(33238-32-3)

Safety Data

• Hazardous Substances Data: 33238-32-3(Hazardous Substances Data)

Usage

Chemical class

isoindole-1,3-diones

Structure

1H-isoindole-1,3(2H)-dione core with a 2-methyl-5-nitrophenyl substituent

Potential applications

pharmaceutical and medicinal chemistry

Biological activities

antimicrobial, anticancer, and anti-inflammatory properties

Research interest

synthesis and biological evaluation for drug discovery and chemical biology

Upstream product

• 85-44-9 phthalic anhydride 
• 99-55-8 2-methyl-5-nitroaniline 

Downstream Products

• 92437-60-0 N-(5-amino-2-methyl-phenyl)-phthalimide 

Relevant articles and documents

Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives

A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.