33240-22-1

Basic information

• Product Name: 2-Butenoic acid, 3-[(3-methoxyphenyl)amino]-, ethyl ester
• CAS NO: 33240-22-1
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Mol File: 33240-22-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-[(3-methoxyphenyl)amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-[(3-methoxyphenyl)amino]-, ethyl ester(33240-22-1)
• EPA Substance Registry System: 2-Butenoic acid, 3-[(3-methoxyphenyl)amino]-, ethyl ester(33240-22-1)

Safety Data

• Hazardous Substances Data: 33240-22-1(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 536-90-3 m-Anisidine 

Downstream Products

• 86210-91-5 ethyl 7-methoxy-2-methylquinoline-3-carboxylate 
• 75896-68-3 4-chloro-7-methoxy-2-methylquinoline 
• 59611-54-0 4-chloro-5-methoxy-2-methyl-quinoline 
• 165112-03-8 7-hydroxy-2-methylquinoline 
• 19490-87-0 7-methoxy-2-methylquinoline 
• 854674-83-2 (2-acetylamino-4-methoxy-phenyl)-glyoxylic acid 
• 103624-90-4 7-methoxy-2-methylquinolin-4-ol 
• 870654-48-1 3-(3-methoxyphenylamino)butyric acid ethyl ester 
• 907998-93-0 5-benzyl-7-methoxy-1-(4-methoxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline 
• 907998-88-3 1-benzyl-7-methoxy-2-methyl-2,3-dihydro-1H-quinolin-4-one 
• 907999-12-6 7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-2H-pyrazolo[4,3-c]quinoline 
• 907999-09-1 5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline 
• 907999-05-7 3-acetyl-1-benzyl-7-methoxy-2,3-dihydro-1H-quinolin-4-one 
• 907998-99-6 7-methoxy-1-(4-methoxyphenyl)-4-methyl-1H-pyrazolo[4,3-c]quinoline 

Relevant articles and documents

Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis

Efficiency is a key organizing principle in modern natural product synthesis. Practical criteria include time, cost, and effort expended to synthesize the target, which tracks with step-count and scale. The execution of a natural product synthesis, that is, the sum and identity of each reaction employed therein, falls along a continuum of chemical (abiotic) synthesis on one extreme, followed by the hybrid chemoenzymatic approach, and ultimately biological (biosynthesis) on the other, acknowledging the first synthesis belongs to Nature. Starting materials also span a continuum of structural complexity approaching the target with constituent elements on one extreme, followed by petroleum-derived and "chiral pool"building blocks, and complex natural products (i.e., semisynthesis) on the other. Herein, we detail our approach toward realizing the first synthesis of (-)-melodinine K, a complex bis-indole alkaloid. The total syntheses of monomers (-)-tabersonine and (-)-16-methoxytabersonine employing our domino Michael/Mannich annulation is described. Isolation of (-)-tabersonine from Voacanga africana and strategic biotransformation with tabersonine 16-hydroxylase for site-specific C-H oxidation enabled a scalable route. The Polonovski-Potier reaction was employed in biomimetic fragment coupling. Subsequent manipulations delivered the target. We conclude with a discussion of efficiency in natural products synthesis and how chemical and biological technologies define the synthetic frontier.

Synthesis and biological screening of some new novel indole derivatives

Synthesis of some novel indole derivatives has been undertaken by the reaction of 1,4-benzoquinone with ethyl-β-(arylamino)-crotonates in the presence/absence of nitrogen atmosphere. The products 1a-o have been screened for their antimicrobial activity an

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a]pyridine moiety

Recently we reported on overcoming the species difference of our first orally active non-peptide bradykinin (BK) B2 receptor antagonists, incorporating an 8-[[3-(N-acylglycyl-N-methylamino)-2,6-dichlorobenzyl]oxy]- 3-halo-2-methylimidazo[1,2-α]