33245-76-0

Usage

InChI:InChI=1/C10H10BrNO5/c1-16-9-3-6(8(13)5-11)7(12(14)15)4-10(9)17-2/h3-4H,5H2,1-2H3

Upstream product

• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 4101-32-0 4',5'-dimethoxy-2'-nitroacetophenone 

Downstream Products

• 49667-20-1 Diaethyl-<4,5-dimethoxy-2-aminophenacyl>-phosphonat 
• 851531-88-9 6-(4,5-dimethoxy-2-nitro-phenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde 
• 851531-87-8 6-(4,5-dimethoxy-2-nitro-phenyl)-imidazo[2,1-b]thiazole 
• 49666-95-7 Diaethyl-<4,5-dimethoxy-2-nitrophenacyl>-phosphonat 
• 49667-18-7 2-iodo-1-(4,5-dimethoxy-2-nitrophenyl)ethanone 

Relevant academic research and scientific papers

Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2′,3′:2,3]imidazo[4,5-c]quinoline

This paper reports synthesis and antitumor activity of new guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2′,3′:2,3]imidazo[4,5-c]quinoline. The compounds were tested as potential antitumor agents at the National Cancer Institute. The effect of the guanylhydrazone of 2-chloro-6-(2,5-dimethoxy-4-nitrophenyl) imidazo[2,1-6]thiazole-5-carbaldehyde (41) was investigated, and it was found to be an inhibitor of Complex III of the mitochondrial respiratory chain and is able to induce apoptosis in the cell lines HT29 and HL60.