3325-11-9

Basic information

• Product Name: 5-AMINOBENZOTRIAZOLE
• Synonyms: TIMTEC-BB SBB005649;5-AMINOBENZOTRIAZOLE;1h-benzotriazol-5-amine;1H-Benzotriazol-5-ylamine;5-Amino-1H-benzotriazole;2H-Benzotriazol-5-amine;2H-benzotriazol-5-ylamine;1H-benzo[d][1,2,3]triazol-5-aMine
• CAS NO: 3325-11-9
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Mol File: 3325-11-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 152-154°C
• Boiling Point: 387.4°Cat760mmHg
• Flash Point: 216.5°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 3.29E-06mmHg at 25°C
• Refractive Index: 1.806
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.61±0.40(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 121262
• CAS DataBase Reference: 5-AMINOBENZOTRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINOBENZOTRIAZOLE(3325-11-9)
• EPA Substance Registry System: 5-AMINOBENZOTRIAZOLE(3325-11-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37-26
• RIDADR: 1325
• TSCA: Yes
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 3325-11-9(Hazardous Substances Data)

Usage

Uses

5-Amino-1H-benzotriazole is used as azole building block.

InChI:InChI=1/C6H6N4/c7-4-1-2-5-6(3-4)9-10-8-5/h1-3H,7H2,(H,8,9,10)

Upstream product

• 2338-12-7 5-nitrobenzotriazole 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 40800-64-4 3-methylsulfanyl-1,3-dihydroindol-2-one 
• 1219937-84-4 C₁₈H₂₁N₇O 

Relevant articles and documents

Discovery of benzotriazole-azo-phenol/aniline derivatives as antifungal agents

A series of benzotriazole-azo-phenol/aniline derivatives were prepared and evaluated for their antifungal activities against six phytopathogenic fungi such as Fusarium graminearum, Fusarium solani, Alternaria alternate, Valsa mali, Botrytis cinerea, and Curvularia lunata. Among them, compounds IIf, IIn, and IIr showed a broad-spectrum of potent antifungal activities. Especially some compounds displayed 3.5–10.8 folds more potent activities than carbendazim against A. alternata and C. lunata. Notably, compounds IIc, IIm, and IIr exhibited good protective and therapeutic effects against B. cinerea at 200 μg/mL. Their structure-activity relationships were also discussed.

Pyrazole compounds

Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

4-N-BENZAZOLYLAMINO DERIVATIVES OF 3-Y-3-BUTEN-2-ONE

Ethoxymethylene derivatives of 2,4-pentanedione (Ia), 3-oxobutanenitrile (Ib), methyl (Ic) or ethyl (Id) 3-oxobutanoate give with 4- or 5-aminobenzimidazole or benzotriazole, respectively, under mild conditions products of nucleophilic substitution II-V.Structure of these compounds was discussed on the basis of their spectral measurements -IR, UV, 1H, 13C NMR and mass spectra.