33278-46-5 Usage
General Description
4-Pyridinecarboxamidine, also known as nicotinamidine, is a chemical compound with the formula C6H7N3O. It is a derivative of pyridine and is a white solid at room temperature. 4-pyridinecarboxamidine is a precursor in the synthesis of various heterocyclic compounds and has pharmaceutical and medicinal applications. It has been used in the development of potential anti-inflammatory and anti-cancer drugs, as well as in the treatment of conditions such as diabetes and Alzheimer's disease. Additionally, it has been studied for its potential to inhibit the growth of certain bacteria and parasites, making it of interest in the field of medical research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 33278-46-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,2,7 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 33278-46:
(7*3)+(6*3)+(5*2)+(4*7)+(3*8)+(2*4)+(1*6)=115
115 % 10 = 5
So 33278-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N3.C2H4O2/c7-6(8)5-1-3-9-4-2-5;1-2(3)4/h1-4H,(H3,7,8);1H3,(H,3,4)
33278-46-5Relevant articles and documents
Evaluation of O-alkyl and aryl sulfonyl aromatic and heteroaromatic amidoximes as novel potent DNA photo-cleavers
Papastergiou,Perontsis,Gritzapis,Koumbis,Koffa,Psomas,Fylaktakidou
, p. 351 - 360 (2016/03/22)
Several stable O-alkyl and aryl sulfonyl conjugated p-nitro-Ph and o-, m-, p-pyridine N′-hydroxy imidamides, were subjected to UV irradiation at 312 nm with supercoiled circular plasmid DNA pBluescript KS II. The generated amidinyl and sulfonyloxyl radicals led to effective DNA photo-cleavage. Both alkyl and aryl sulfonyl derivatives were active and the order p-pyridine > p-nitro-Ph > o-pyridine > m-pyridine was schematized for the N′-hydroxy imidamides moiety. Calf thymus-DNA affinity studies which comprised UV interactions, viscosity experiments and competitive studies with ethidium bromide showed good to excellent affinity of the compounds. These properties revealed sulfonyl amidoximes as novel effective DNA-photo-cleavers and may serve in the discovery of new leads for "on demand" biotechnological and medical applications.
