3328-77-6Relevant articles and documents
2-Acetyl-4-aminoresorcinol derivatives: synthesis, antioxidant activity and molecular docking studies
Guerra-Vargas, María A.,Rosales-Hernández, Martha C.,Martínez-Fonseca, Nadhynee,Padilla-Martínez, Itzia,Fonseca-Sabater, Yadira,Martínez-Ramos, Federico
, p. 1186 - 1197 (2018)
In this study, we synthesized new phenolic compounds that have the potential to serve as antioxidants and slow the effects of free radicals and oxidizing agents, which is beneficial for human health. Three resorcinol derivatives (new amide compounds) were generated by acetylation, nitration, and reduction. The structures of the products were determined by spectroscopic methods. The antioxidant activities of the new compounds were evaluated in vitro by redox reactions with the free radicals of the diammonium salt of 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+●) and 1,1-diphenyl-2-picrylhydrazyl (DPPH●). The tested compounds showed antioxidant activities similar to that of resveratrol, a natural product known to affect a wide range of intracellular mediators. These derivatives were also submitted to docking simulations to evaluate their possible interactions with the enzyme myeloperoxidase. This analysis showed potential interactions with pockets “A” and “B” in the enzyme, and the best interaction was detected between succinic-amide (4) and pocket A.
Highly efficient nitration of phenolic compounds by zirconyl nitrate
Selvam, J. Jon Paul,Suresh,Rajesh,Reddy, S. Ravinder,Venkateswarlu
, p. 2507 - 2509 (2007/10/03)
Zirconyl nitrate was found to be an excellent reagent in the nitration of phenol and substituted phenols to give nitrated phenols. This procedure works efficiently on most of the examples at room temperature yielding nitro derivatives in fair to good yields with high regioselectivity.
Reaction of Cerium(IV) Ammonium Nitrate with Aralkyl and Aromatic Ketones
Chawla, H. Mohindra,Mittal, Ram S.,Johny, C. J.
, p. 992 - 993 (2007/10/02)
Fluoren-9-one on treatment with cerium(IV) ammonium nitrate (CAN) yields five compounds which have been identified as 3-nitro-; 2-nitro; 1,8-dinitro; 2,7-dinitro; and 2,7-dinitrofluoren-9-ones.Acetophenone on treatment with CAN, yields only benzoic acid while 2,4-dihydroxyacetophenone on similar treatment yields three compounds which have been identified as 2,4-dihydroxy-5-nitro; 2,4-dihydroxy-3-nitro; and 2,4-dihydroxy-3,5-dinitro-acetophenones.