33282-15-4

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-HYDROXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID is used as a building block for the synthesis of pharmaceuticals due to its chemical structure that can be incorporated into various drug molecules, potentially leading to the development of new treatments for different diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 5-(4-HYDROXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID is used as a precursor in the synthesis of agrochemicals, contributing to the development of new compounds for pest control and crop protection.
Used in Anti-inflammatory and Analgesic Applications:
5-(4-HYDROXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID is used as an active pharmaceutical ingredient for its potential anti-inflammatory and analgesic properties, offering a new avenue for the treatment of pain and inflammation.
Used in Corrosion Inhibition:
In the metalworking industry, 5-(4-HYDROXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID is used as a corrosion inhibitor to protect metal surfaces from degradation, enhancing the longevity and performance of metal components in various applications.

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 425609-97-8 methyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate 
• 33282-16-5 5-(4-methoxyphenyl)isoxazole-3-carboxylic acid 

Downstream Products

• 1232028-35-1 5-(4-Hydroxy-phenyl)-isoxazole-3-carboxylic acid {2-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide 
• 1188373-23-0 5-(4-hydroxyphenyl)isoxazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethylphenoxy)piperidin-1-yl]ethyl}amide 

Relevant academic research and scientific papers

Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents

In this study, a concise synthetic method of psammaplin A was achieved from 3-bromo-4-hydroxybenzaldahyde and hydantoin through a four-step synthesis via Knoevenagel condensation, hydrolysis, oximation and amidation in 37% overall yield. A collection of novel psammaplin A analogs focused on the variations of substituents at the benzene ring and modifications at the oxime moiety were synthesized. Among all the synthesized compounds, 5d and 5e showed better HDAC inhibition than psammaplin A and comparable cytotoxicity against four cancer cell lines (PC-3, MCF-7, A549 and HL-60). Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.