33282-22-3

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Chlorophenyl)isoxazole-3-carboxylic acid is used as a building block for the synthesis of various drugs and bioactive molecules. Its unique structure and reactivity make it a valuable tool for drug discovery and development, contributing to the creation of new therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-(4-chlorophenyl)isoxazole-3-carboxylic acid is used for studying its potential biological activities and exploring its applications in the development of novel therapeutic agents.
Used in Agrochemicals:
5-(4-Chlorophenyl)isoxazole-3-carboxylic acid may also have applications in the agrochemical industry, where it can be utilized as a building block for the synthesis of agrochemicals with specific properties and reactivity.
Used in Materials Science:
In materials science, 5-(4-chlorophenyl)isoxazole-3-carboxylic acid can be employed in the development of new materials with unique properties, such as advanced polymers or composites, due to its chemical structure and functional groups.

InChI:InChI=1/C10H6ClNO3/c11-7-3-1-6(2-4-7)9-5-8(10(13)14)12-15-9/h1-5H,(H,13,14)

Upstream product

• 81282-12-4 ethyl 5-(4-chlorophenyl)isoxazole-3-carboxylate 
• 86425-09-4 4-(4-chlorophenyl)but-3-en-2-one oxime 
• 3160-40-5 4-(4-chlorophenyl)-3-buten-2-one 
• 99-91-2 para-chloroacetophenone 
• 65356-49-2 ethyl 4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoate 

Downstream Products

• 1105633-27-9 C₂HF₃O₂*C₁₈H₁₂ClN₃O₂ 
• 1334687-03-4 5-(4-chlorophenyl)-N,N-di-n-hexylisoxazole-3-carboxamide 
• 1334687-02-3 5-(4-chlorophenyl)-N,N-di-n-propylisoxazole-3-carboxamide 

Relevant academic research and scientific papers

Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents

The complex pathophysiology of Alzheimer's disease (AD) has prompted researchers to develop multitarget-directed molecules to find an effective therapy against the disease. In this context, a novel series of N-(1-benzylpiperidin-4-yl)-5-arylisoxazole-3-ca

Biofilm inhibition and DNA binding studies of isoxazole-triazole conjugates in the development of effective anti-bacterial agents

Isoxazole-triazole conjugates (8a-q) were synthesized using click chemistry approach and their biological activities were explored to develop novel antibacterial agents. In vitro antibacterial screening against Gram-positive as well as Gram-negative bacterial strains identified compounds 8b and 8m with potent inhibitory potential against selective bacterial cells. 8b showed IC50 value of 67.6 μg/mL against P. aeruginosa while 8m exhibited better activity against Gram-positive bacteria S. pneumoniae and E. faecalis having IC50 values 74.13 and 44.7 μg/mL, respectively. Effect on growth kinetics of the bacterial cells as well as cytotoxicity studies on human embryonic kidney cells (HEK293) further supports their biological potential. Compound 8m significantly inhibited biofilm formation of E. coli cells visualized by scanning electron microscopy (SEM) analysis. The interaction of these compounds with ctDNA, as their possible mode of action, was studied using multi-spectroscopic techniques and molecular docking. The data suggested that compound 8m intercalate in the minor groove of DNA.

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-

Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives

In this work, a novel series of arylisoxazole-phenylpiperazines were designed, synthesized, and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our results revealed that [5-(2-chlorophenyl)-1,2-oxazol-3-yl](4-phenylpiperazin

1,2,3-Triazole-isoxazole based acetylcholinesterase inhibitors: Synthesis, biological evaluation and docking study

In this work, a series of derivatives containing 1,2,3-triazole and isoxazole were synthesized. All of them were evaluated as novel dual AChE inhibitors. Most of synthesized compounds showed moderate to good inhibitory potency toward AChE. Among them, N-(

Novel indole-isoxazole hybrids: Synthesis and in vitro anti-cholinesterase activity

Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction

Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives

New derivatives of triazole-isoxazole were synthesized through a four-step reaction starting from various ethyl 4-aryl-2,4-dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF-7 and T-47D).

O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids

A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.