332841-60-8

Upstream product

• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 

Downstream Products

• 332841-56-2 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate 
• 1213240-87-9 2-(8-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate 
• 332841-57-3 3-formyl-2-(3'',4''-dimethoxy-2''-mesyloxyphenyl)-1-(3',4'-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 332841-59-5 1-(3,4-dimethoxy-phenyl)-2-(2-hydroxy-4,5-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-3-carbaldehyde 
• 181423-71-2 14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Relevant academic research and scientific papers

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents

A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.

An efficient synthesis of lamellarin alkaloids: Synthesis of lamellarin G trimethyl ether

A general and efficient synthesis of lamellarin alkaloids is described. The synthesis involves the formation of the core pyrrolo[2,1-a]isoquinoline, followed by the formation of the lactone ring.