332865-74-4

Upstream product

• 241478-33-1 tert-butyl (4S)-4-<(1R)-1-hydroxy-3-phenyl-2-propynyl>-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 291534-37-7 (2R)-methoxy-1-(hydroxymethyl)-(1S)-(4'-iodophenylsulfonyl)amino-4-phenylbut-3-yne 
• 291534-34-4 tert-butyl (4S,1'R)-2,2-dimethyl-4-(1'-methoxy-3'-phenylprop-2'-ynyl)oxazolidine-3-carboxylate 
• 291534-35-5 tert-butyl (1S,2R)-N-[2-methoxy-1-(hydroxymethyl)-4-phenylbut-3-ynyl]carbamate 
• 291534-36-6 (1S,2R)-2-methoxy-1-(hydroxymethyl)-1-amino-4-phenylbut-3-yne 
• 536-74-3 phenylacetylene 

Downstream Products

• 332864-98-9 methyl (2R)-{[4'-methoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-(3R)-methoxy-5-phenylpent-4-ynoate 

Relevant academic research and scientific papers

Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines

A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typically