332875-18-0Relevant academic research and scientific papers
Regioselective synthesis of 13C1-labeled 2-deoxyribonolactones
Hayes, Michael P,Hatala, Paul J,Sherer, Brian A,Tong, Xiaohong,Zanatta, Nilo,Borer, Philip N,Kallmerten, James
, p. 1515 - 1524 (2007/10/03)
Syntheses of the five regioselectively 13C1-labeled 5-O-benzyl-2-deoxyribonolactones are described. 13C1-Labeled deoxyribonolactones were prepared by addition of KCN to epoxides 7 and subsequent lactonization of the resulting nitriles. Integration of the independent schemes leading to the five isotopomers of 9 results in an efficient and cost effective preparation of labeled mixtures of 13C mono-labeled deoxyribonolactones. These mixtures are the pivotal intermediates in the preparation of 'population labeled' 13C-labeled nucleoside phosphoramidites for solid-phase oligonucleotide synthesis.
