332887-50-0

Upstream product

• 108-94-1 cyclohexanone 
• 766443-66-7 1-[(E)-2-(1-oxaspiro[2.5]oct-2-yl)vinyl]-1H-1,2,3-benzotriazole 
• 766443-81-6 1-[(E)-1-methyl-2-(1-oxaspiro[2.5]oct-2-yl)vinyl]-1H-1,2,3-benzotriazole 
• 17530-95-9 1-(4-chlorophenylsulfinyl)propan-2-one 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant academic research and scientific papers

β-acylvinyl anion and dianion equivalents: Lithiation of 1-[(2EZ)-3-chloroprop-2-enyl]-1H-1,2,3-benzotriazole: Preparation and elaboration of 1-(2-oxiranylvinyl)-1H-benzotriazoles

The allyllithium generated from 1-[(2EZ)-3-chloroprop-2-enyl]-1H-1,2,3- benzotriazole (5) and LDA, in the presence of HMPA, reacts with enolizable and nonenolizable carbonyls solely at the CCl terminus to give 1-(2-oxiranylvinyl) benzotriazoles 6a-g in 61

Convenient formation of 4-hydroxyalk-2-en-1-one functionality via a Knoevenagel-type carbon chain elongation reaction of aldehyde with 1-arylsulfinylalkan-2-one

A highly functionalized four-carbon unit, 4-hydroxyalk-2-en-1-one functionality [R2CH(OH)CH= CHCOR1], was conveniently prepared by a reaction of an aldehyde (R2CH2CHO) with a 1-(arylsulfinyl)alkan-2-one [ArS(O)CH2COR1] in the presence of diethylamine (Knoevenagel condition). Other functional groups, such as carbonyl and hydroxy groups, in both of the alkyl chains (R1, R2) did not prevent this reaction. This reaction was used to conveniently prepare (±)-(11E)-13-hydroxy-10-oxooctadec-11-enoic acid (14), having cytotoxic activity, and its analogues from undec-10-enoic acid in good yield.