332903-60-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-Ethylphenyl)-2,3,5,6-tetrafluorobenzenaMine is used as an intermediate in the preparation of (arylamino)phenylacetic acids, which are known as COX-2 cyclooxygenase inhibitors. These inhibitors play a crucial role in the development of medications for treating pain and inflammation, as they help reduce the production of prostaglandins, which are responsible for these symptoms.
As a COX-2 inhibitor, N-(4-Ethylphenyl)-2,3,5,6-tetrafluorobenzenaMine contributes to the development of nonsteroidal anti-inflammatory drugs (NSAIDs) that are effective in managing conditions such as arthritis, menstrual cramps, and other inflammatory disorders. Additionally, these inhibitors have been studied for their potential in reducing the risk of colorectal cancer and Alzheimer's disease.

Upstream product

• 769-39-1 2,3,5,6-tetraflourophenol 
• 20172-36-5 α-chloro-N-(p-ethylphenyl)acetamide 
• 363-72-4 Pentafluorobenzene 
• 589-16-2 4-aminoethylbenzene 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 700-17-4 2,3,5,6-tetrafluoroaniline 

Relevant academic research and scientific papers

Method for preparing acid

The invention relates to a method for preparing an acid, and belongs to the technical field of pharmacy. The method comprises: carrying out a reaction on a reaction material and an alkali in an organic solvent, making the reaction product contact hydrazin

Removal of heavy metals from organic reaction mixtures: Preparation and application of functionalized resins

Using a toolbox, sulfur and amine ligands are attached to a variety of hydrophobic and hydrophilic resins, and the combinations were tested for the removal of heavy metals from a number of products, prepared by metal-catalyzed reactions. As a result, cheap combinations of silica resins and simple polyamines proved to be among the most effective metal scavengers particularly in apolar solvents such as cyclohexane. Expensive cyclic polyamines are not suitable, owing to kinetic retardation of complexation. Functionalized PEGbased polymers, originally designed for solid phase synthesis, show promising performance as metal scavengers. The results are discussed and compared to alternative approaches for purification such as salt-formation and chemical downstream transformation.

Process for phenylacetic acid derivatives

A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds

Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. Graphical Abstract.

Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives

Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1is chloro or fluoro; R2is hydrogen or fluoro; R3is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4is hydrogen or fluoro; and R5is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.