333-88-0Relevant academic research and scientific papers
PROCESS FOR PRODUCING ALDEHYDE COMPOUND OR KETONE COMPOUND WITH USE OF MICROREACTOR
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Page/Page column 21-22; 35-36; 38-39, (2010/11/24)
The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield comprises a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.
Room-temperature Swern oxidations by using a microscale flow system
Kawaguchi, Tatsuya,Miyata, Hiroyuki,Ataka, Kikuo,Mae, Kazuhiro,Yoshida, Jun-Ichi
, p. 2413 - 2416 (2007/10/03)
(Equation Presented) Residence time controlled reaction: The Swern oxidation of alcohols has been accomplished by using a microscale flow system, consisting of micromixers and microscale tube reactors (see schematic representation ; DMSO = dimethylsulfoxide, TFAA = trifluoroacetic anhydride), at higher temperatures (-20 to 20°C) than those for conventional macroscale batch systems (-50°C or below).
