33304-34-6Relevant academic research and scientific papers
Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: Synthesis of quinolactacide and marinamide
Simic, Milena,Tasic, Gordana,Jovanovic, Predrag,Petkovic, Milos,Savic, Vladimir
, p. 2125 - 2133 (2018/03/27)
A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N-allyl imides as starting materials. The nucleophilic addition of a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yie
Pyrolytic cyclisation reactions of 3-azolylpropenyl alcohols; unexpectedly facile thermal decomposition of 5H-pyrrolo-[2,1-a]isoindole
Clark, Bernard A. J.,Despinoy, Xavier L. M.,McNab, Hamish,Sommerville, Craig C.,Stevenson, Elizabeth
, p. 2049 - 2051 (2007/10/03)
Flash vacuum pyrolysis (FVP) of 3-azolylpropenyl alcohols 5-7, 12 or 15 at 650-700°C (10-2-10-3 Torr) causes loss of water and cyclisation to give 3H-pyrrolizine 8 and its analogues 9, 10, 13 and 16; at higher temperatures (e.g. 900°C) 5H-pyrrolo[2,1-a]isoindole 13 decomposes by loss of HCN to give naphthalene 18 and benzofulvene 19 and the mechanism of this transformation is studied by deuterium labelling.
