33322-91-7Relevant academic research and scientific papers
Combined thiourea dioxidewater: An effective reusable catalyst for the synthesis of polyhydroquinolines via hantzsch multicomponent coupling
Kumar, Neeraj,Verma, Sanny,Jain, Suman L.
, p. 920 - 922 (2012)
Thiourea dioxide in water was found to be an efficient and reusable organocatalytic system for the one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch-type coupling of aldehyde, dimedone, acetoacetate, and ammonium acetate under mild reaction conditions. Operational simplicity, the use of an economically affordable catalyst, environmentally benign conditions, high product yields, and reusability of the catalyst system were the advantageous features of the developed method.
P-toluene sulfonic acid catalyzed one-pot synthesis of unsymmetrical 1,4-dihydropyridines derivatives via hantzsch reaction
Peng, Hua-Nan,Peng, Xiao-Ming,Zheng, Da-Gui
experimental part, p. 1833 - 1837 (2012/01/13)
A simple, inexpensive and efficient one-pot synthesis of a series of unsymmetrical 1,4-dihydropyridines derivatives using p-toluene sulfonic acid as catalyst at room temperature was achieved in excellent yields from the four-component Hantzsch condensation reactions of various aromatic aldehydes, 1,3-cyclohexanedione, methyl acetoacetate (or ethyl acetoacetate) and ammonium acetate in a little methanol (or ethanol). The procedure possesses the advantages of short reaction time, high yields, an environmental friendly procedure as well as easy isolation of products.
