33328-08-4

Upstream product

• 591-50-4 iodobenzene 
• 705-62-4 N,N-dimethyl-N'-phenylthiourea 
• 722-56-5 diphenyliodonium nitrate 
• 66003-76-7 Diphenyliodonium triflate 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 
• 98-80-6 phenylboronic acid 
• 1483-72-3 diphenyliodonium chloride 

Relevant academic research and scientific papers

Copper-Catalyzed S-Arylation of Arylthioureas by Using Diaryliodonium Salts

A convenient and efficient copper-catalyzed S-arylation of arylthioureas using diaryliodonium salts is reported. The desired arylisothioureas were synthesized in good yields in the presence of CuCl as catalyst and K 2 CO 3 as base, and a wide variety of functional groups on the arylthioureas and diaryliodonium salts were tolerated. The protocol affords an alternative synthesis of some potentially useful biological and pharmaceutical compounds.

Chemoselective Chan-Lam Coupling Reactions between Benzimidazoline-2-thiones and Arylboronic Acids

An efficient Chan-Lam-type methodology for the selective synthesis of S-arylbenzimidazoles and N,S-diarylbenzimidazoles was developed. The selectivity was controlled by varying the amount of the catalyst Cu(OAc)2·H2O, temperature, an

Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water

An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds.

An Efficient Chan–Lam S-Arylation of Arylthioureas with Arylboronic Acids

A convenient and efficient protocol has been developed for the preparation of aryl-isothioureas based on the Chan–Lam C–S coupling reaction. The desired aryl-isothioureas were synthesized in good yields (up to 95 %) in the presence of Cu(OAc)2·H2O as catalyst and bipyridine as ligand. A variety of functional groups on the aryl-thiourea and arylboronic acid reagents are tolerated. The method features mild reaction conditions and good yields, thereby illustrating its practical synthetic value in organic synthesis.

Copper-Catalyzed C-S Cross-Coupling Reaction: S-Arylation of Arylthioureas

A simple and efficient copper-catalyzed S-arylation of aryl-thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.