33328-13-1

Basic information

• Product Name: 4-methoxyphenyl-N,N-dimethyl-N'-phenylcarbamimidothioate
• Synonyms: 4-methoxyphenyl-N,N-dimethyl-N'-phenylcarbamimidothioate
• CAS NO: 33328-13-1
• Molecular Weight: 286.398
• Mol File: 33328-13-1.mol

Chemical Properties

• CAS DataBase Reference: 4-methoxyphenyl-N,N-dimethyl-N'-phenylcarbamimidothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxyphenyl-N,N-dimethyl-N'-phenylcarbamimidothioate(33328-13-1)
• EPA Substance Registry System: 4-methoxyphenyl-N,N-dimethyl-N'-phenylcarbamimidothioate(33328-13-1)

Safety Data

• Hazardous Substances Data: 33328-13-1(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 705-62-4 N,N-dimethyl-N'-phenylthiourea 

Relevant articles and documents

Copper-Catalyzed C-S Cross-Coupling Reaction: S-Arylation of Arylthioureas

A simple and efficient copper-catalyzed S-arylation of aryl-thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water

An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds.