3333-06-0 Usage
Chemical structure
1-(9H-fluoren-9-yl)piperidine is a chemical compound consisting of a piperidine ring with a fluorenyl group attached to it.
Application
It is commonly used in medicinal chemistry and drug discovery as a building block for the synthesis of various pharmaceutical compounds.
Structural advantage
The fluorenyl group in the molecule provides additional rigidity and stability, making it an attractive structural motif in drug design.
Potential use
1-(9H-fluoren-9-yl)piperidine has been studied for its potential as a ligand for various receptors and as a precursor for the synthesis of biologically active molecules.
Versatile reactivity
Its unique structure and versatile reactivity make it a valuable tool in the development of new drugs and pharmaceuticals.
Research focus
The compound is of interest to researchers due to its potential applications in the creation of novel therapeutic agents and its ability to interact with various biological targets.
Synthesis
The compound can be synthesized through various chemical reactions, often involving the formation of the piperidine ring and subsequent attachment of the fluorenyl group.
Biological activity
The compound may exhibit biological activity depending on its specific structural features and the receptors it interacts with, which can be further explored for drug development purposes.
Safety and toxicity
As with any chemical compound, the safety and toxicity of 1-(9H-fluoren-9-yl)piperidine should be carefully evaluated before its use in drug development or other applications.
Legal and regulatory status
The legal and regulatory status of 1-(9H-fluoren-9-yl)piperidine may vary depending on the country or region, and it is essential to comply with local laws and regulations when handling or using 1-(9H-fluoren-9-yl)piperidine.
Check Digit Verification of cas no
The CAS Registry Mumber 3333-06-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,3 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3333-06:
(6*3)+(5*3)+(4*3)+(3*3)+(2*0)+(1*6)=60
60 % 10 = 0
So 3333-06-0 is a valid CAS Registry Number.
3333-06-0Relevant academic research and scientific papers
Synthesis of a 9-fluorenone derived β-amino alcohol ligand depicting high catalytic activity and pronounced non-linear stereochemical effects
Reddy, Katamreddy Subba,Sola, Lluis,Moyano, Albert,Pericas, Miquel A.,Riera, Antoni
, p. 165 - 176 (2007/10/03)
The Jacobsen epoxidation of 9-alkylidenefluorenes 4a (ethylidene), 4b (benzylidene) and 4c (1-naphtylmethylene) with standard (R,R)-manganese salen catalyst has been studied. Both conversion and enantioselectivity depend on the steric bulk of the olefin substituent, best results being recorded with 4b (96% yield, 99% ee). The stereochemical course of the epoxidation of 4a is highly dependent on temperature and solvent, the ee of the resulting epoxide (S)-5a varying from 22% (-18°C, CH2Cl2) to 49% (55°C, MTBE). The lithium perchlorate induced ring-opening of 5a with piperidine in MeCN affords a mixture of regioisomeric amino alcohols 3a/2a arising from the amine attack at the more substituted and less substituted carbons, respectively. The 3a/2a ratio can be modulated by the LiClO4 concentration and the reaction temperature, and varies from 44:56 to 91:9. An independent, completely regiocontrolled synthesis of 3a has been developed involving ring-opening by the more substituted carbon of epoxide 5a with diisopropoxytitanium diazide, reduction of azidoalcohol 10a (H2, Pd/C) and cycloalkylation (1,5- dibromopentane, K2CO3) of the amino alcohol 11a. The amino alcohol 3a exhibits a positive nonlinear stereochemical effect in its action as a ligand for the enantioselective addition of Et2Zn to benzaldehyde. The use of regiochemically pure 3a of >99% ee has been studied in the addition of Et2Zn to a representative family of aldehydes [19 examples, 93.6% mean ee]. The use of the directly available 9:1 mixture of 3a and 2a derived from 46-47% ee 5a as a ligand system for the enantioselective addition of Et2Zn to aldehydes [8 examples, 93.1% mean ee] is also reported.
